Head & neck · 2014
Multi-institutional retrospective study for the evaluation of ocular function-preservation rates in maxillary sinus squamous cell carcinomas with orbital invasion.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Sakashita Tomohiro, Hayashi Ryuichi, Homma Akihiro, Matsuura Kazuto, Kato Kengo, Kawabata Kazuyoshi, Monden Nobuya, Hasegawa Yasuhisa, Onitsuka Tetsuro, Fujimoto Yasushi, Iwae Shigemichi, Okami Kenji, Matsuzuka Takashi, Yoshino Kunitoshi, Fujii Masato
Аннотация
BACKGROUND: The purpose of this retrospective analysis was to evaluate ocular function and survival rates among treatment modalities in patients with maxillary sinus cancer with orbital invasion.
METHODS: Eighty-seven patients were classified according to the main treatment modality. Ocular function preservation rates and survival rates were evaluated for each therapeutic modality.
RESULTS: The 5-year overall survival rate for the en bloc resection, conservative surgery, superselective intra-arterial chemotherapy, and radiotherapy (RADPLAT), intravenous chemoradiotherapy (IV-CRT) was 70%, 35%, 49%, and 31%, respectively. The ocular function preservation rate for each group was 15%, 27%, 30%, and 17%, respectively. In the en bloc resection group, there was no significant difference in the 5-year overall survival rate between patients with orbital exenteration and those without orbital exenteration (72% vs 71%; p = .9321).
CONCLUSION: The en bloc resection group showed a favorable survival rate but a low preservation rate. Preservation of orbital contents did not reduce the survival rate.
METHODS: Eighty-seven patients were classified according to the main treatment modality. Ocular function preservation rates and survival rates were evaluated for each therapeutic modality.
RESULTS: The 5-year overall survival rate for the en bloc resection, conservative surgery, superselective intra-arterial chemotherapy, and radiotherapy (RADPLAT), intravenous chemoradiotherapy (IV-CRT) was 70%, 35%, 49%, and 31%, respectively. The ocular function preservation rate for each group was 15%, 27%, 30%, and 17%, respectively. In the en bloc resection group, there was no significant difference in the 5-year overall survival rate between patients with orbital exenteration and those without orbital exenteration (72% vs 71%; p = .9321).
CONCLUSION: The en bloc resection group showed a favorable survival rate but a low preservation rate. Preservation of orbital contents did not reduce the survival rate.
Предметные рубрики MeSH
AdultAgedAged, 80 and overAntineoplastic AgentsCarcinoma, Squamous CellChemoradiotherapyEyeFemaleHead and Neck NeoplasmsHumansInfusions, Intra-ArterialIntention to Treat AnalysisKaplan-Meier EstimateMaleMaxillary Sinus NeoplasmsMiddle AgedOrbitOrbit EviscerationOrbital NeoplasmsRecovery of FunctionRetrospective StudiesSquamous Cell Carcinoma of Head and Neck