Transactions of the Royal Society of Tropical Medicine and Hygiene · 2022
The impact of Loa loa microfilaraemia on research subject retention during a whole sporozoite malaria vaccine trial in Equatorial Guinea.
Клиническое исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Manock Stephen R, Nsue Vicente Urbano, Olotu Ally, Mpina Maximillian, Nyakarungu Elizabeth, Raso José, Mtoro Ali, Ondo Mangue Martín Eka, Ntutumu Pasialo Beltrán Ekua, Nguema Rufino, Riyahi Pouria, Schindler Tobias, Daubenberger Claudia, Church L W Preston, Billingsley Peter F, Richie Thomas L, Abdulla Salim, Hoffman Stephen L
Аннотация
Loa loa microfilariae were found on thick blood smears (TBSs) from 8 of 300 (2.7%) residents of Bioko Island, Equatorial Guinea, during a Plasmodium falciparum sporozoite malaria vaccine clinical trial. Only one subject was found to have microfilaraemia on his first exam; parasites were not discovered in the other seven until subsequent TBSs were performed, at times many weeks into the study. All infected individuals were asymptomatic, and were offered treatment with diethylcarbamazine, per national guidelines. L. loa microfilaraemia complicated the enrolment or continued participation of these eight trial subjects, and only one was able to complete all study procedures. If ruling out loiasis is deemed to be important during clinical trials, tests that are more sensitive than TBSs should be performed.