Zhonghua bing li xue za zhi = Chinese journal of pathology · 1999
[Clinicopathological study of mucosa-associated lymphoid tissue lymphoma of salivary glands].
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Shi Q, Zhang T, Yan X, Shou B
Аннотация
OBJECTIVE: To study the histopathological features and pathogenesis of mucosa associated lymphoid tissue lymphoma (MALT-oma) of salivary glands.
METHODS: Surgical specimens from 27 cases of MALT-oma of salivary glands were studied using paraffin-embedded section, immunohistochemical method (SP method) and electron microscope.
RESULTS: 12 tumors were located in the pariotid glands, the other 15 in the submandibular glands. Much of the MALT-oma of the salivary glands were composed of diffuse centrocyte-like (CCL) cells with "lymphoepithelial lesions". Immunohistochemically, CD20 expression was found to be positive and CD45RO expression was negative in all MALT-omas of salivary glands.
CONCLUSIONS: Most of the MALT-omas are low grade malignant tumors and the tumor cells have a "homing back" phenomenon. A small number of MALT-omas can become highly malignant tumors with poor prognosis. Acquired MALT may develop as a reaction to autoimmune disease and/or infection. Hyperimmune reaction and MALT hyperplasia under continuous stimulation may result in myoepithelial sialadenitis and develop into MALT-oma of salivary glands.
METHODS: Surgical specimens from 27 cases of MALT-oma of salivary glands were studied using paraffin-embedded section, immunohistochemical method (SP method) and electron microscope.
RESULTS: 12 tumors were located in the pariotid glands, the other 15 in the submandibular glands. Much of the MALT-oma of the salivary glands were composed of diffuse centrocyte-like (CCL) cells with "lymphoepithelial lesions". Immunohistochemically, CD20 expression was found to be positive and CD45RO expression was negative in all MALT-omas of salivary glands.
CONCLUSIONS: Most of the MALT-omas are low grade malignant tumors and the tumor cells have a "homing back" phenomenon. A small number of MALT-omas can become highly malignant tumors with poor prognosis. Acquired MALT may develop as a reaction to autoimmune disease and/or infection. Hyperimmune reaction and MALT hyperplasia under continuous stimulation may result in myoepithelial sialadenitis and develop into MALT-oma of salivary glands.