MORPHOMETRIC ASSESSMENT OF STRUCTURAL CHANGES IN THE VASCULAR BED OF DUODENUM IN ANIMALS WITH OBSTRUCTIVE CHOLESTASIS.

Aim of the research - comprehensive morphometric assessment of the structural and spatial organization of the circulatory system of the duodenum in obstructive cholestasis in intact animals. Three days after the simulated obstructive cholestasis in 3 experimental animals, on examination of radiographs there is a tendency to reorient the arterial and venous bed of the duodenum. Analysis of morphometric parameters also showed a tendency to constriction of arteries and varicose veins. Some narrowing of the arteries was evidenced by a decrease in the diameters of the main trunks of the vascular order (D0) almost throughout the period of the studied vascular bed. The same trend was observed in the morphometric assessment of daughter branches (D1, D2). The degree of circulatory disorders, disorders of the microcirculatory tract are accompanied by an increase in the angles of arteries and fusion of veins, increased asymmetry of the vascular bed of the duodenum, narrowing of the lumen of arteries and thickening of their walls are objective criteria for assessing the degree of mechanical jaundice, predicting the reversibility of their changes.