A literature review on the interplay of childhood trauma, PCOS, and attachment theory: implications for relationship functioning.

Polycystic Ovary Syndrome (PCOS) is a multidimensional endocrine disorder marked by reproductive, metabolic, and psychological symptoms. Emerging research links childhood trauma to the development and exacerbation of PCOS, mediated by hormonal dysregulation, inflammation, and attachment-related psychological factors. This review expands the existing literature by incorporating inflammatory, epigenetic, and stress-related biological pathways; identity and attachment-based mechanisms; and sociocultural influences. It also evaluates integrated treatment approaches that combine endocrinological and psychological care. A comprehensive biopsychosocial model is proposed to inform future trauma-informed and culturally responsive interventions. Limitations and future research directions are discussed.