Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2014
Immunohistochemical profile of oral mucosal and head and neck cutaneous melanoma.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Alaeddini Mojgan, Etemad-Moghadam Shahroo
Аннотация
BACKGROUND: In addition to ultraviolet radiation exposure, various molecular markers may differ between oral mucosal and cutaneous head and neck melanomas and lead to variations in their biologic behavior and prognosis. The aim of this study was to compare four such markers, namely microphthalmia transcription factor (MITF), P75, P53, and Ki-67 in malignant melanomas originating from the oral cavity and head and neck skin.
METHODS: A total of 19 oral mucosal and 23 head and neck cutaneous melanomas were subjected to immunohistochemical analysis using antibodies against MITF, P75, P53, and Ki-67. Statistical comparison of data was performed by t-test and chi-square analysis (P < 0.05).
RESULTS: Significant differences in MITF (P = 0.016) and Ki-67 (P = 0.002) were observed between oral mucosal and cutaneous melanomas. P75 (P = 0.80) and P53 (P = 0.76) did not differ significantly, between these locations.
CONCLUSIONS: According to the results obtained in this study, the biological properties of cutaneous and mucosal melanoma differ, especially regarding MITF and Ki-67.
METHODS: A total of 19 oral mucosal and 23 head and neck cutaneous melanomas were subjected to immunohistochemical analysis using antibodies against MITF, P75, P53, and Ki-67. Statistical comparison of data was performed by t-test and chi-square analysis (P < 0.05).
RESULTS: Significant differences in MITF (P = 0.016) and Ki-67 (P = 0.002) were observed between oral mucosal and cutaneous melanomas. P75 (P = 0.80) and P53 (P = 0.76) did not differ significantly, between these locations.
CONCLUSIONS: According to the results obtained in this study, the biological properties of cutaneous and mucosal melanoma differ, especially regarding MITF and Ki-67.
Предметные рубрики MeSH
AdultAgedAged, 80 and overBiomarkers, TumorCell MembraneCell ProliferationCytoplasmFacial NeoplasmsFemaleGingival NeoplasmsHead and Neck NeoplasmsHumansImmunohistochemistryKi-67 AntigenMaleMelanomaMicrophthalmia-Associated Transcription FactorMiddle AgedMouth MucosaMouth NeoplasmsNerve Tissue ProteinsPalatal NeoplasmsReceptors, Nerve Growth FactorSkin NeoplasmsTumor Suppressor Protein p53