Brain and behavior · 2020
The relationship between epilepsy and cognitive function in benign childhood epilepsy with centrotemporal spikes.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Li Yihan, Sun Yulei, Zhang Tingting, Shi Qi, Sun Jintao, Xiang Jing, Chen Qiqi, Hu Zheng, Wang Xiaoshan
Аннотация
INTRODUCTION: This study was aimed to explore the relationship between neural network changes in newly diagnosed children with Benign Childhood Epilepsy with Centrotemporal Spikes (BECTS) and cognitive impairment.
METHODS: Children's cognition was evaluated using the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV). Magnetoencephalographic (MEG) data of 18 healthy children and 22 BECTS patients were recorded in order to construct a functional connectivity (FC) network, which was quantified by graph theory (GT).
RESULTS: The mean age of the control group was 7.94 ± 1.89 years, and the mean age of BECTS patients was 8.14 ± 1.73 years. Our results show that the WISC-IV index scores in the BECTS group were significantly lower than those in the control group. Besides, the FC network pattern of BECTS patients changed significantly in the 12-30, 30-80, and 250-500 Hz frequency band. The local functional connections between posterior cingulate cortex (PCC) and frontal lobe varied significantly in 12-30, 80-250, and 250-500 Hz. Our GT analysis shows that the connection strength of BECTS patients increases significantly in the 12-30 Hz frequency band, the path length decreases significantly in the 12-30 Hz and 30-80 Hz frequency bands, with the clustering coefficient decreasing significantly in the 12-30 Hz, 30-80 Hz, and 250-500 Hz frequency bands. Correlation analysis showed that the full-scale IQ (FSIQ) was positively correlated with the 12-30 Hz clustering coefficient, verbal comprehension index (VCI) was positively correlated with the 250-500 Hz clustering coefficient, perceptual reasoning index (PRI) was positively correlated with the 12-30 Hz clustering coefficient, and perceptual reasoning index (PSI) was negatively correlated with the 12-30 Hz path length.
CONCLUSION: There is a trend of cognitive impairment in patients with early BECTS. This trend of cognitive impairment in early BECTS children may be related to the changes in the FC network pattern.
METHODS: Children's cognition was evaluated using the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV). Magnetoencephalographic (MEG) data of 18 healthy children and 22 BECTS patients were recorded in order to construct a functional connectivity (FC) network, which was quantified by graph theory (GT).
RESULTS: The mean age of the control group was 7.94 ± 1.89 years, and the mean age of BECTS patients was 8.14 ± 1.73 years. Our results show that the WISC-IV index scores in the BECTS group were significantly lower than those in the control group. Besides, the FC network pattern of BECTS patients changed significantly in the 12-30, 30-80, and 250-500 Hz frequency band. The local functional connections between posterior cingulate cortex (PCC) and frontal lobe varied significantly in 12-30, 80-250, and 250-500 Hz. Our GT analysis shows that the connection strength of BECTS patients increases significantly in the 12-30 Hz frequency band, the path length decreases significantly in the 12-30 Hz and 30-80 Hz frequency bands, with the clustering coefficient decreasing significantly in the 12-30 Hz, 30-80 Hz, and 250-500 Hz frequency bands. Correlation analysis showed that the full-scale IQ (FSIQ) was positively correlated with the 12-30 Hz clustering coefficient, verbal comprehension index (VCI) was positively correlated with the 250-500 Hz clustering coefficient, perceptual reasoning index (PRI) was positively correlated with the 12-30 Hz clustering coefficient, and perceptual reasoning index (PSI) was negatively correlated with the 12-30 Hz path length.
CONCLUSION: There is a trend of cognitive impairment in patients with early BECTS. This trend of cognitive impairment in early BECTS children may be related to the changes in the FC network pattern.