Leukemia & lymphoma · 2020
Prognostic factors affecting survival in children and adolescents with HIV and Hodgkin lymphoma in South Africa.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Geel Jennifer Ann, Eyal Katherine Claire, Hendricks Marc Gerald, Myezo Khumo Hope, Stones David Kenneth, Omar Fareed, Goga Yasmin, van Zyl Anel, van Emmenes Barry, Vaithilingum Manickavallie, Irusen Shaegan, Bandini Rossella Marina, Wedi Oloko, Rowe Biance, Ballot Daynia Elizabeth, Metzger Monika L, South African Children’s Cancer Study Group
Аннотация
South African children with Hodgkin lymphoma (HL) and human immunodeficiency virus (HIV) have low 5-year overall survival (OS) rates. In this retrospective multicenter study, 271 South African pediatric patients with HL were studied to determine OS and prognostic factors in those with HIV and HL. Univariate risk factor analysis was performed to analyze prognostic factors. The 29 HIV-infected patients were younger (p = .021), more likely to present with wasting (0.0573), stunting (0.0332), and Stage IV disease (p = .000) than HIV-uninfected patients. The 5- and 10-year OS of HIV-infected patients of 49% and 45% versus 84% and 79%, respectively for HIV-uninfected patients (p = .0001) appeared to be associated with hypoalbuminemia (<20 g/dL) and CD4 percentage of <15%. Causes of death in the HIV-infected group included disease progression (6/14), infection (4/14), unknown (3/14), and second malignancy (1/14). HIV-infected pediatric patients with HL experience increased mortality due to post-therapy opportunistic and nosocomial infections.