Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
Life Course Trajectories of Body Mass Index and Risk of Cancer in Adulthood: Systematic Review and Meta-Analysis.
Систематический обзорСтатьяМетаанализПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Behboudi-Gandevani Samira, Haugan Tommy, Moreira Nayla Cristina Do Vale, Arntzen Ellen Christin, Hutchinson Moira Strand, Nichols Melanie, Bidhendi-Yarandi Razieh
Аннотация
OBJECTIVE: This systematic review and meta-analysis aimed to identify common life-course body mass index (BMI) trajectories (childhood/adulthood to adulthood) and their impact on risk of cancer overall and cancer at different sites in adulthood.
METHODS: Observational studies were identified that assessed the association of BMI trajectories with cancer risks from databases published in English. The pooled effect sizes were estimated using a random-effects model.
FINDINGS: A total of 24 eligible studies were included in the meta-analysis. Transitioning from normal weight to obesity was significantly associated with an increased risk of colorectal cancer (effect size [ES] = 1.170, 95% CI: 1.096, 1.245), pancreatic cancer (ES = 1.337, 95% CI: 1.247, 1.426), kidney cancer (ES = 2.122, 95% CI: 1.619, 2.624), and liver cancer (ES = 1.777, 95% CI: 1.261, 2.293), compared to those in the stable normal weight trajectory. No significant difference in the risk of breast or prostate cancer was observed when comparing various BMI trajectories to a stable normal BMI trajectory.
CONCLUSION: The findings suggest that lifetime BMI trajectories influence cancer risk, with a transition from normal BMI to higher levels associated with an increased risk of cancer. The impact varied by trajectory and cancer type. Further studies are needed to confirm these findings.
METHODS: Observational studies were identified that assessed the association of BMI trajectories with cancer risks from databases published in English. The pooled effect sizes were estimated using a random-effects model.
FINDINGS: A total of 24 eligible studies were included in the meta-analysis. Transitioning from normal weight to obesity was significantly associated with an increased risk of colorectal cancer (effect size [ES] = 1.170, 95% CI: 1.096, 1.245), pancreatic cancer (ES = 1.337, 95% CI: 1.247, 1.426), kidney cancer (ES = 2.122, 95% CI: 1.619, 2.624), and liver cancer (ES = 1.777, 95% CI: 1.261, 2.293), compared to those in the stable normal weight trajectory. No significant difference in the risk of breast or prostate cancer was observed when comparing various BMI trajectories to a stable normal BMI trajectory.
CONCLUSION: The findings suggest that lifetime BMI trajectories influence cancer risk, with a transition from normal BMI to higher levels associated with an increased risk of cancer. The impact varied by trajectory and cancer type. Further studies are needed to confirm these findings.