Journal of pediatric gastroenterology and nutrition · 2026
Abdominal pain in pediatric immunoglobulin A vasculitis: Risk factors and severity predictors in a multicenter cohort.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Gomes Francisco Hugo Rodrigues, Maronese Natalia, Magalhaes Leticia Lizardo, Aragon Davi Casale, Clemente Gleice, Terreri Maria Teresa, Len Claudio Arnaldo, Almeida Rozana Gasparello de, Rodrigues Marta Cristine Felix, Sztajnbok Flavio, Steuer Lia Vineyard, França Matheus Santos, Silva Clovis Artur Almeida da, Ferriani Virginia Paes Leme, Carvalho Luciana Martins de
Аннотация
OBJECTIVES: To identify risk factors for abdominal pain and predictors of complicated abdominal pain in pediatric immunoglobulin A vasculitis (IgAV).
METHODS: Retrospective multicenter study including children and adolescents (≤18 years) fulfilling the European League Against Rheumatism/Pediatric Rheumatology International Trials Organization/Pediatric Rheumatology European Society (EULAR/PRINTO/PRES) criteria for IgAV and followed at four tertiary centers in Brazil. Factors associated with abdominal pain in the overall cohort and with complicated abdominal pain (defined as abdominal pain associated with intussusception, intestinal bleeding, or acute abdomen) were evaluated during the first 3 months of the disease and at the end of follow-up. Univariate analyses, a pre-specified multivariable log-binomial regression model, and receiver operating characteristic (ROC) curve analysis were performed.
RESULTS: Among the 687 pediatric patients with IgAV, 420 (61.1%) developed abdominal pain within the first 3 months and 428 (62.3%) by the end of follow-up (median follow-up of 54.1 months [interquartile range 50.7-59.3]). Among patients with abdominal pain, 22.2% developed complications. Prolonged purpuric/petechial rash (>29 days; RRadj 1.78, 95% confidence interval [CI] 1.09-2.91) and leukocytosis (>13,500/mm3; RRadj 2.30, 95% CI 1.41-3.73) were independently associated with complications. Leukocytosis showed good discriminatory performance for predicting acute abdomen (area under the curve 0.813, 95% CI 0.704-0.923).
CONCLUSION: Prolonged purpuric/petechial rash and leukocytosis were independently associated with complicated abdominal pain. Leukocytosis may help identify children at higher risk of acute abdomen.
METHODS: Retrospective multicenter study including children and adolescents (≤18 years) fulfilling the European League Against Rheumatism/Pediatric Rheumatology International Trials Organization/Pediatric Rheumatology European Society (EULAR/PRINTO/PRES) criteria for IgAV and followed at four tertiary centers in Brazil. Factors associated with abdominal pain in the overall cohort and with complicated abdominal pain (defined as abdominal pain associated with intussusception, intestinal bleeding, or acute abdomen) were evaluated during the first 3 months of the disease and at the end of follow-up. Univariate analyses, a pre-specified multivariable log-binomial regression model, and receiver operating characteristic (ROC) curve analysis were performed.
RESULTS: Among the 687 pediatric patients with IgAV, 420 (61.1%) developed abdominal pain within the first 3 months and 428 (62.3%) by the end of follow-up (median follow-up of 54.1 months [interquartile range 50.7-59.3]). Among patients with abdominal pain, 22.2% developed complications. Prolonged purpuric/petechial rash (>29 days; RRadj 1.78, 95% confidence interval [CI] 1.09-2.91) and leukocytosis (>13,500/mm3; RRadj 2.30, 95% CI 1.41-3.73) were independently associated with complications. Leukocytosis showed good discriminatory performance for predicting acute abdomen (area under the curve 0.813, 95% CI 0.704-0.923).
CONCLUSION: Prolonged purpuric/petechial rash and leukocytosis were independently associated with complicated abdominal pain. Leukocytosis may help identify children at higher risk of acute abdomen.