Fertility and sterility · 2008
Absence of chlamydial deoxyribonucleic acid from testicular and epididymal samples from men with obstructive azoospermia.
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Sripada Sreebala, Amezaga Maria Rosario, Hamilton Mark, McKenzie Hamish, Templeton Allan, Bhattacharya Siladitya
Аннотация
OBJECTIVE: To identify Chlamydia trachomatis DNA by polymerase chain reaction in the upper genital tract of men with obstructive azoospermia compared with men seeking vasectomy reversal.
DESIGN: Case-control study.
SETTING: Tertiary referral center, Aberdeen Royal Infirmary, Aberdeen, United Kingdom.
PATIENT(S): Cases were men with idiopathic obstructive azoospermia, and controls were men with azoospermia secondary to vasectomy.
INTERVENTION(S): Chlamydia trachomatis-specific DNA test by polymerase chain reaction on testicular and epididymal biopsy samples, as well as epididymal aspirate.
MAIN OUTCOME MEASURE(S): Presence of Chlamydia trachomatis DNA.
RESULT(S): We did not detect the presence of Chlamydia trachomatis-specific DNA by polymerase chain reaction in the epididymis or testis of 36 asymptomatic men with obstructive azoospermia (14 cases, 22 controls).
CONCLUSION(S): Our hypothesis that unrecognized, asymptomatic chlamydial infection will lead to complete bilateral obstruction of the male genital tract remains unproven.
DESIGN: Case-control study.
SETTING: Tertiary referral center, Aberdeen Royal Infirmary, Aberdeen, United Kingdom.
PATIENT(S): Cases were men with idiopathic obstructive azoospermia, and controls were men with azoospermia secondary to vasectomy.
INTERVENTION(S): Chlamydia trachomatis-specific DNA test by polymerase chain reaction on testicular and epididymal biopsy samples, as well as epididymal aspirate.
MAIN OUTCOME MEASURE(S): Presence of Chlamydia trachomatis DNA.
RESULT(S): We did not detect the presence of Chlamydia trachomatis-specific DNA by polymerase chain reaction in the epididymis or testis of 36 asymptomatic men with obstructive azoospermia (14 cases, 22 controls).
CONCLUSION(S): Our hypothesis that unrecognized, asymptomatic chlamydial infection will lead to complete bilateral obstruction of the male genital tract remains unproven.