Gastroenterology · 1993
The configuration of the human gastroduodenal junction in the separate emptying of liquids and solids.
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Brown B P, Schulze-Delrieu K, Schrier J E, Abu-Yousef M M
Аннотация
BACKGROUND: The stomach separately empties liquids and large particulate solids. The present study aimed to better define the mechanisms responsible for this separate emptying in humans.
METHODS: Real-time ultrasound images of the gastroduodenal junction were tape-recorded in normal volunteers after they ingested a test meal consisting of beans and chicken broth.
RESULTS: During early emptying, beans were retained along the gastric greater curve as it bulged caudally. When the pylorus was open, liquids flowed over the beans into the duodenum. Emptying of the occasional bean that appeared in the antrum was blocked by closure of the pylorus. Later, the antrum was tubular in shape with reduced area of cross section, yet the percent narrowing of the lumen with each contraction remained constant. Beans were now in close contact with the contracting antral wall and were transformed into small particles. Only in this state were solids allowed through the pylorus.
CONCLUSIONS: Mechanisms by which the human stomach "sieves" liquids from solids include (1) sedimentation of solids in the dependent portion of the stomach, while liquids are "decanted" into the duodenum in early emptying; (2) blockade of large particles from entering the duodenum by closure of the pylorus; and (3) grinding of large particles by the gastric antrum in late emptying.
METHODS: Real-time ultrasound images of the gastroduodenal junction were tape-recorded in normal volunteers after they ingested a test meal consisting of beans and chicken broth.
RESULTS: During early emptying, beans were retained along the gastric greater curve as it bulged caudally. When the pylorus was open, liquids flowed over the beans into the duodenum. Emptying of the occasional bean that appeared in the antrum was blocked by closure of the pylorus. Later, the antrum was tubular in shape with reduced area of cross section, yet the percent narrowing of the lumen with each contraction remained constant. Beans were now in close contact with the contracting antral wall and were transformed into small particles. Only in this state were solids allowed through the pylorus.
CONCLUSIONS: Mechanisms by which the human stomach "sieves" liquids from solids include (1) sedimentation of solids in the dependent portion of the stomach, while liquids are "decanted" into the duodenum in early emptying; (2) blockade of large particles from entering the duodenum by closure of the pylorus; and (3) grinding of large particles by the gastric antrum in late emptying.