Journal of affective disorders · 2020
Integrative analysis of genome-wide association study and common meQTLs for exploring the effects of DNA methylation on the development of neuroticism.
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Zhao Shuang, Liu Zhi-Gang
Аннотация
BACKGROUND: Neuroticism is one of the important traits of personality, which has strong genetic components. However, the underlying genetic mechanism is still unclear.
METHODS: To better understand the genetic basis of neuroticism, we conducted an integrative analysis of genome-wide association studies (GWAS) and life course consistent methylation quantitative trait loci (meQTLs) data. The GWAS data of neuroticism was derived from a published study of neuroticism (including 170,906 subjects). Life course consistent meQTLs were obtained from a large scale longitudinal meQTLs analysis (including 1,018 mother-child pairs).Gene prioritization, pathway and tissue/cell type enrichment analyses were implemented by DEPICT.
RESULTS: We identified multiple genes, pathways and tissues associated with neuroticism, such as NEIL2 (P value = 1.31 × 10-2), ARHGAP27 (P value = 1.40 × 10-2), REACTOME_CLATHRIN_DERIVED_VESICLE_BUDDING(P value =4.92 × 10-6) ,REACTOME_TRANS:GOLGI_NETWORK_VESICLE_BUDDING (P value =4.92 × 10-6), frontal lobe(P value =3.83 × 10-3) and visual cortex (P value =8.46 × 10-3).
CONCLUSIONS: Our results provide novel insights for understanding the genetic mechanism of neuroticism.
METHODS: To better understand the genetic basis of neuroticism, we conducted an integrative analysis of genome-wide association studies (GWAS) and life course consistent methylation quantitative trait loci (meQTLs) data. The GWAS data of neuroticism was derived from a published study of neuroticism (including 170,906 subjects). Life course consistent meQTLs were obtained from a large scale longitudinal meQTLs analysis (including 1,018 mother-child pairs).Gene prioritization, pathway and tissue/cell type enrichment analyses were implemented by DEPICT.
RESULTS: We identified multiple genes, pathways and tissues associated with neuroticism, such as NEIL2 (P value = 1.31 × 10-2), ARHGAP27 (P value = 1.40 × 10-2), REACTOME_CLATHRIN_DERIVED_VESICLE_BUDDING(P value =4.92 × 10-6) ,REACTOME_TRANS:GOLGI_NETWORK_VESICLE_BUDDING (P value =4.92 × 10-6), frontal lobe(P value =3.83 × 10-3) and visual cortex (P value =8.46 × 10-3).
CONCLUSIONS: Our results provide novel insights for understanding the genetic mechanism of neuroticism.