Cerebellar Volume and Disease Staging in Parkinson's Disease: An ENIGMA-PD Study.
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Kerestes Rebecca, Laansma Max A, Owens-Walton Conor, Perry Andrew, van Heese Eva M, Al-Bachari Sarah, Anderson Tim J, Assogna Francesca, Aventurato Ítalo K, van Balkom Tim D, Berendse Henk W, van den Berg Kevin R E, Betts Rebecca, Brioschi Ricardo, Carr Jonathan, Cendes Fernando, Clark Lyles R, Dalrymple-Alford John C, Dirkx Michiel F, Druzgal Jason, Durrant Helena, Emsley Hedley C A, Garraux Gaëtan, Haroon Hamied A, Helmich Rick C, van den Heuvel Odile A, João Rafael B, Johansson Martin E, Khachatryan Samson G, Lochner Christine, McMillan Corey T, Melzer Tracy R, Mosley Philip E, Newman Benjamin, Opriessnig Peter, Parkes Laura M, Pellicano Clelia, Piras Fabrizio, Pitcher Toni L, Poston Kathleen L, Rango Mario, Roos Annerine, Rummel Christian, Schmidt Reinhold, Schwingenschuh Petra, Silva Lucas S, Smith Viktorija, Squarcina Letizia, Stein Dan J, Tavadyan Zaruhi, Tsai Chih-Chien, Vecchio Daniela, Vriend Chris, Wang Jiun-Jie, Wiest Roland, Yasuda Clarissa L, Young Christina B, Jahanshad Neda, Thompson Paul M, van der Werf Ysbrand D, Harding Ian H, ENIGMA-Parkinson's Study
Аннотация
OBJECTIVE: To quantify cross-sectional regional cerebellar lobule volumes using three dimensional T1-weighted anatomical brain magnetic resonance imaging from the global ENIGMA-PD working group.
METHODS: Cerebellar parcellation was performed using a deep learning-based approach from 2487 people with PD and 1212 age and sex-matched controls across 22 sites. Linear mixed effects models compared total and regional cerebellar volume in people with PD at each Hoehn and Yahr (HY) disease stage, to an age- and sex- matched control group. Associations with motor symptom severity and Montreal Cognitive Assessment scores were investigated.
RESULTS: Overall, people with PD had a regionally smaller posterior lobe (dmax = -0.15). HY stage-specific analyses revealed a larger anterior lobule V bilaterally (dmax = 0.28) in people with PD in HY stage 1 compared to controls. In contrast, smaller bilateral lobule VII volume in the posterior lobe was observed in HY stages 3, 4, and 5 (dmax = -0.76), which was incrementally lower with higher disease stage. Within PD, cognitively impaired individuals had lower total cerebellar volume compared to cognitively normal individuals (d = -0.17).
CONCLUSIONS: We provide evidence of a dissociation between anterior "motor" lobe and posterior "non-motor" lobe cerebellar regions in PD. Whereas less severe stages of the disease are associated with larger motor lobe regions, more severe stages of the disease are marked by smaller non-motor regions. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.