Voxel-Wise Logistic Regression and Leave-One-Source-Out Cross Validation for white matter hyperintensity segmentation.

Many algorithms have been proposed for automated segmentation of white matter hyperintensities (WMH) in brain MRI. Yet, broad uptake of any particular algorithm has not been observed. In this work, we argue that this may be due to variable and suboptimal validation data and frameworks, precluding direct comparison of methods on heterogeneous data. As a solution, we present Leave-One-Source-Out Cross Validation (LOSO-CV), which leverages all available data for performance estimation, and show that this gives more realistic (lower) estimates of segmentation algorithm performance on data from different scanners. We also develop a FLAIR-only WMH segmentation algorithm: Voxel-Wise Logistic Regression (VLR), inspired by the open-source Lesion Prediction Algorithm (LPA). Our variant facilitates more accurate parameter estimation, and permits intuitive interpretation of model parameters. We illustrate the performance of the VLR algorithm using the LOSO-CV framework with a dataset comprising freely available data from several recent competitions (96 images from 7 scanners). The performance of the VLR algorithm (median Similarity Index of 0.69) is compared to its LPA predecessor (0.58), and the results of the VLR algorithm in the 2017 WMH Segmentation Competition are also presented.