Hematology (Amsterdam, Netherlands) · 2025
Analysis of risk factors for relapse after allogeneic hematopoietic stem cell transplantation in acute leukemia.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Jiawen, Zhu Han, Miao Kourong
Аннотация
BACKGROUND: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective, and in many cases, the only treatment for curing malignant blood diseases. However, post-transplant relapse is the primary factor affecting survival rates.
METHODS: We conducted a retrospective analysis of 123 patients with acute leukemia undergoing allo-HSCT at Jiangsu Provincial People's Hospital from August 2017 to June 2023 to discuss the risk factors for relapse in acute leukemia (AL) patients after allo-HSCT.
RESULTS: Among the 123 patients, 41experienced relapse, with 30 cases of relapse within one year. Multivariable analysis showed that pre-transplant MRD (+) and NR (HR 2.32, 95%CI 1.18-4.54, P = 0.014), post-transplant MRD (+) (HR 2.13, 95%CI 1.04-4.36, P = 0.016), cGVHD (-) (HR 0.48, 95%CI 0.23-0.97, P = 0.041) and age < 40 (HR 0.44, 95%CI 0.23-0.83, P = 0.011) were independent risk factors for relapse after allo-HSCT.
CONCLUSIONS: Data from our center indicated that pre-transplant MRD (+) and NR, post-transplant MRD (+), cGVHD (-) and age < 40 are independent risk factors affecting relapse after allo-HSCT.
METHODS: We conducted a retrospective analysis of 123 patients with acute leukemia undergoing allo-HSCT at Jiangsu Provincial People's Hospital from August 2017 to June 2023 to discuss the risk factors for relapse in acute leukemia (AL) patients after allo-HSCT.
RESULTS: Among the 123 patients, 41experienced relapse, with 30 cases of relapse within one year. Multivariable analysis showed that pre-transplant MRD (+) and NR (HR 2.32, 95%CI 1.18-4.54, P = 0.014), post-transplant MRD (+) (HR 2.13, 95%CI 1.04-4.36, P = 0.016), cGVHD (-) (HR 0.48, 95%CI 0.23-0.97, P = 0.041) and age < 40 (HR 0.44, 95%CI 0.23-0.83, P = 0.011) were independent risk factors for relapse after allo-HSCT.
CONCLUSIONS: Data from our center indicated that pre-transplant MRD (+) and NR, post-transplant MRD (+), cGVHD (-) and age < 40 are independent risk factors affecting relapse after allo-HSCT.