Head & neck · 2010
Salivary gland carcinomas in children and adolescents: a population-based study, with comparison to adult cases.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Sultan Iyad, Rodriguez-Galindo Carlos, Al-Sharabati Sereen, Guzzo Marco, Casanova Michela, Ferrari Andrea
Аннотация
BACKGROUND: Salivary gland carcinomas are rare malignancies, particularly in young individuals in whom only scanty data are available from published studies.
METHODS: We searched the SEER database (1973-2006) for patients with a reported diagnosis of salivary gland carcinoma; children/adolescents (<20 years old) were compared with adults.
RESULTS: We identified 263 children/adolescents (58% girls) and 12,571 adults (43% women). The most common histology was mucoepidermoid carcinoma in both groups, but the percentages of other histologies were different. Children/adolescents had more favorable features with most tumors being localized, with no extension to adjacent tissues or lymphatic spread (76% vs 50% in adults, p < .001). Also most tumors were well differentiated or moderately differentiated (88% vs 49% in adults, p < .001). The 5-year overall survival for children/adolescents was 95% ± 1.5%, compared with 59% ± 0.5% for adults (p < .001).
CONCLUSION: When compared with adults, salivary gland carcinomas in children/adolescents are less advanced, and have more favorable features and better outcome.
METHODS: We searched the SEER database (1973-2006) for patients with a reported diagnosis of salivary gland carcinoma; children/adolescents (<20 years old) were compared with adults.
RESULTS: We identified 263 children/adolescents (58% girls) and 12,571 adults (43% women). The most common histology was mucoepidermoid carcinoma in both groups, but the percentages of other histologies were different. Children/adolescents had more favorable features with most tumors being localized, with no extension to adjacent tissues or lymphatic spread (76% vs 50% in adults, p < .001). Also most tumors were well differentiated or moderately differentiated (88% vs 49% in adults, p < .001). The 5-year overall survival for children/adolescents was 95% ± 1.5%, compared with 59% ± 0.5% for adults (p < .001).
CONCLUSION: When compared with adults, salivary gland carcinomas in children/adolescents are less advanced, and have more favorable features and better outcome.