Epilepsia · 2003
Rasmussen syndrome: multifocal spread of inflammation suggested from MRI and PET findings.
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Maeda Yumi, Oguni Hirokazu, Saitou Yoshiaki, Mutoh Ayako, Imai Kaoru, Osawa Makiko, Fukuyama Yukio, Hori Tomokatsu, Yamane Fumitaka, Kubo Osamu, Ishii Kenji, Ishiwata Kiichi
Аннотация
BACKGROUND: A 6-year-old girl with Rasmussen syndrome (RS) showed multiple small high-signal-intensity areas independently in the right hemisphere by fluid-attenuated inversion recovery (FLAIR) imaging on magnetic resonance imaging (MRI) 1 year after the onset of epilepsy.
METHODS: MRI performed 4 months later demonstrated a further increase in the number of these foci and enlargement in the size of the previous FLAIR lesions.
RESULTS: An [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) study showed a strong, spotty uptake in the right temporooccipital regions, corresponding to the sites of continuous EEG seizure discharges. In contrast, [11C]methionine PET demonstrated multifocal uptake regions, which corresponded anatomically to the FLAIR lesions, suggesting sites of underlying chronic inflammation.
CONCLUSIONS: These neuroimaging findings suggested that the inflammatory process in RS spreads either multifocally at the same time, as seen in this case, or from one discrete area to the adjacent region, as reported previously.
METHODS: MRI performed 4 months later demonstrated a further increase in the number of these foci and enlargement in the size of the previous FLAIR lesions.
RESULTS: An [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) study showed a strong, spotty uptake in the right temporooccipital regions, corresponding to the sites of continuous EEG seizure discharges. In contrast, [11C]methionine PET demonstrated multifocal uptake regions, which corresponded anatomically to the FLAIR lesions, suggesting sites of underlying chronic inflammation.
CONCLUSIONS: These neuroimaging findings suggested that the inflammatory process in RS spreads either multifocally at the same time, as seen in this case, or from one discrete area to the adjacent region, as reported previously.
Предметные рубрики MeSH
Autonomic Nervous System DiseasesCarbon RadioisotopesCerebral CortexChildDisease ProgressionDominance, CerebralEncephalitisEpilepsia Partialis ContinuaEpilepsyEpilepsy, Partial, MotorEpilepsy, Temporal LobeFemaleFluorodeoxyglucose F18Follow-Up StudiesHumansImage EnhancementMagnetic Resonance ImagingMethionineOccipital LobeTemporal LobeTomography, Emission-Computed