Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025
Associations between body weight, asthma burden, and type 2 inflammation among under-resourced children.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Thompson David, Visness Cynthia M, Wood Robert A, O'Connor George T, Robison Rachel G, Hershey Gurjit K Khurana, Kercsmar Carolyn M, Chambliss Jeffrey, Liu Andrew H, Johnson Christine, Lovinsky-Desir Stephanie, Bacharier Leonard B, Gern James E, Jackson Daniel J, Busse William W, Gergen Peter J, Teach Stephen J, Rastogi Deepa
Аннотация
BACKGROUND: Overweight/obesity is a risk factor for asthma, particularly in under-resourced children, and contributes to higher disease burden. Type 2 (T2) inflammation, a key characteristic of asthma endotypes, has been inconsistently associated with burden of obesity-related asthma, which may be due to limited overlap between different T2 features, including elevated total serum IgE level, eosinophilia, and allergen sensitization.
OBJECTIVE: To investigate the effects of different T2 features on association of overweight/obesity with asthma burden in under-resourced children.
METHODS: Among 2160 children aged 6 to 20 years from 4 Inner-City Asthma Consortium cohorts, the association of overweight/obesity with asthma burden (unscheduled visits, hospitalizations, exacerbations, asthma control, and pulmonary function) and the effect of T2 features (total IgE level higher than age-specific cutoffs, total eosinophils > 300 cells/µL, or sensitization to ≥2 allergens) on the association were investigated.
RESULTS: The odds (odds ratio [95% CI]) of unscheduled visits were higher among those with overweight/obesity (1.35 [1.04-1.75]) and allergen sensitization (1.35 [1.02-1.80]), hospitalizations were higher among those with elevated total IgE level (2.17 [1.27-3.69]) and eosinophilia (2.80 [1.56-5.21]), and poor asthma control was higher among those with elevated total IgE level (1.27 [1.09-1.41]). Overweight/obesity and all T2 features were associated with lower forced expiratory volume in 1 second/forced vital capacity ratio. There was no synergistic or clinically significant mediating influence of any of T2 features on the association of overweight/obesity with asthma burden.
CONCLUSION: Among under-resourced children with asthma, overweight/obesity and T2 inflammation are largely independently associated with unscheduled visits and pulmonary function deficits. T2 inflammation, but not overweight/obesity, is associated with poor control and hospitalizations.
OBJECTIVE: To investigate the effects of different T2 features on association of overweight/obesity with asthma burden in under-resourced children.
METHODS: Among 2160 children aged 6 to 20 years from 4 Inner-City Asthma Consortium cohorts, the association of overweight/obesity with asthma burden (unscheduled visits, hospitalizations, exacerbations, asthma control, and pulmonary function) and the effect of T2 features (total IgE level higher than age-specific cutoffs, total eosinophils > 300 cells/µL, or sensitization to ≥2 allergens) on the association were investigated.
RESULTS: The odds (odds ratio [95% CI]) of unscheduled visits were higher among those with overweight/obesity (1.35 [1.04-1.75]) and allergen sensitization (1.35 [1.02-1.80]), hospitalizations were higher among those with elevated total IgE level (2.17 [1.27-3.69]) and eosinophilia (2.80 [1.56-5.21]), and poor asthma control was higher among those with elevated total IgE level (1.27 [1.09-1.41]). Overweight/obesity and all T2 features were associated with lower forced expiratory volume in 1 second/forced vital capacity ratio. There was no synergistic or clinically significant mediating influence of any of T2 features on the association of overweight/obesity with asthma burden.
CONCLUSION: Among under-resourced children with asthma, overweight/obesity and T2 inflammation are largely independently associated with unscheduled visits and pulmonary function deficits. T2 inflammation, but not overweight/obesity, is associated with poor control and hospitalizations.