Environmental toxicology and pharmacology · 2025
Mutual oral administration of wood/plastic smoke PM and heavy metals Pb2+/Cd2+: General toxicity effects and ACE2 expression in rats.
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Dziubenko Nataliya, Byelinska Iryna, Dovbynchuk Taisa, Ishchuk Arsen, Velmyk Viktoriia, Korbush Mariia, Paliienko Konstantin, Kalynovska Liliia, Krisanova Nataliya, Pozdnyakova Nataliya, Borisova Tatiana, Tolstanova Ganna
Аннотация
Carbonaceous air pollution particulate matter (PM) and xenobiotic heavy metals, Pb2+ and Cd2+, are hazardous toxicants. PM-associated Pb2+ and Cd2+ are substantial metal components of PM2.5. Here, we analysed general toxicity and ACE2 concentration/expression in rats after combined oral administration of water-suspended smoke PM preparations from wood (WS) or polypropylene (PS) and Pb2+/Cd2+. After combined exposure to Pb2+/Cd2 and WS/PS, turnover of erythrocytes increased (an increase in volume of MCV erythrocytes). The combined effect of Cd2+ and PS had a lymphosuppressive effect. Pb2+/Cd2+ with WS/PS increased the level of myeloperoxidase activity in the mucous membrane of rat colon in all groups. ACE2 concentrations in the blood plasma were not changed in all groups. WS and PS reduced the intensity of positive staining of ACE2 receptors in the mucous membrane of the colon of rats. Therefore, multipollutant heavy metal- and PM-induced effects on general toxicity parameters and ACE2 concentration/expression were revealed.