Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2014
Results of age-dependent anal canal cancer treatment: a single centre retrospective study.
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Claren Audrey, Doyen Jerôme, Falk Alexander T, Benezery Karen, Follana Philippe, Frin Anne-Claire, Hannoun-Lévi Jean-Michel, Cavaglione Gérard, Mari Véronique, Gérard Jean-Pierre, François Eric
Аннотация
BACKGROUND: Information concerning management of anal canal cancer among the elderly is scarce and much less abundant than for younger subjects.
POPULATION AND METHODS: We retrospectively analysed 115 patients treated for anal epidermoid cancer between 2000 and 2010. The population was divided according to age (<70 years and ≥70 years).
RESULTS: Of the 115 patients, 81 (70.4%) were <70 years old and 34 were ≥70 years (29.6%). Tumour characteristics were identical between the two groups and median follow-up was 62 months. Elderly patients had a less favourable performance status (p=0.001) and fewer had received radiochemotherapy (61.8% vs 82.5%, p=0.004). Treatment-related grade 3 and 4 hematologic toxicity was observed more often among elderly subjects. The results at 5 years were less favourable for overall, disease-specific, and disease-free survival (respectively p=0.002, p=0.001, and p=0.001). For patients treated with a curative intent, at 5 years there was no difference between the two groups in terms of overall survival (p=0.2). However, there was a statistically significant difference in favour of the younger group for disease-free survival and metastasis-free survival.
CONCLUSION: If radiochemotherapy can be delivered to elderly subjects with a good general status, the effects appear less favourable than in younger patients.
POPULATION AND METHODS: We retrospectively analysed 115 patients treated for anal epidermoid cancer between 2000 and 2010. The population was divided according to age (<70 years and ≥70 years).
RESULTS: Of the 115 patients, 81 (70.4%) were <70 years old and 34 were ≥70 years (29.6%). Tumour characteristics were identical between the two groups and median follow-up was 62 months. Elderly patients had a less favourable performance status (p=0.001) and fewer had received radiochemotherapy (61.8% vs 82.5%, p=0.004). Treatment-related grade 3 and 4 hematologic toxicity was observed more often among elderly subjects. The results at 5 years were less favourable for overall, disease-specific, and disease-free survival (respectively p=0.002, p=0.001, and p=0.001). For patients treated with a curative intent, at 5 years there was no difference between the two groups in terms of overall survival (p=0.2). However, there was a statistically significant difference in favour of the younger group for disease-free survival and metastasis-free survival.
CONCLUSION: If radiochemotherapy can be delivered to elderly subjects with a good general status, the effects appear less favourable than in younger patients.
Предметные рубрики MeSH
AdultAge FactorsAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsAnus NeoplasmsBrachytherapyCarcinoma, Squamous CellChemoradiotherapyCisplatinDisease-Free SurvivalFemaleFluorouracilFollow-Up StudiesHumansMaleMiddle AgedMitomycinRadiotherapy DosageRetrospective StudiesSurvival RateTumor Burden