Annales de dermatologie et de venereologie · 2013
[Pyoderma gangrenosum with lung involvement treated with infliximab].
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Deregnaucourt D, Buche S, Coopman S, Basraoui D, Turck D, Delaporte E
Аннотация
BACKGROUND: Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis often associated with systemic diseases, particularly chronic inflammatory bowel diseases. Extracutaneous manifestations (articular, ocular, renal, pulmonary, hepatosplenic, muscular) exist, with lung involvement being the most common.
PATIENT AND METHODS: We report a case of PG with skin and lung involvements in a patient treated with high-dose corticosteroids in a setting of severe ulcerative colitis (UC). Lung involvement was diagnosed during the pretreatment assessment performed prior to initiation of anti-TNFα therapy. Infliximab resulted in rapid improvement of the lung and skin lesions.
DISCUSSION: In the event of simultaneous cutaneous PG lesions and lung lesions suggestive of abscess, visceral involvement should be suspected. First-line treatment consists of oral corticosteroids. In our patient, the occurrence of lesions under corticosteroids in UC militated in favour of anti-TNFα therapy, which proved effective.
PATIENT AND METHODS: We report a case of PG with skin and lung involvements in a patient treated with high-dose corticosteroids in a setting of severe ulcerative colitis (UC). Lung involvement was diagnosed during the pretreatment assessment performed prior to initiation of anti-TNFα therapy. Infliximab resulted in rapid improvement of the lung and skin lesions.
DISCUSSION: In the event of simultaneous cutaneous PG lesions and lung lesions suggestive of abscess, visceral involvement should be suspected. First-line treatment consists of oral corticosteroids. In our patient, the occurrence of lesions under corticosteroids in UC militated in favour of anti-TNFα therapy, which proved effective.
Предметные рубрики MeSH
AdolescentAdrenal Cortex HormonesAnalgesicsAntibodies, MonoclonalColectomyColitis, UlcerativeCombined Modality TherapyDrug Therapy, CombinationErgocalciferolsGastrointestinal HemorrhageHumansImmunosuppressive AgentsInfliximabLung DiseasesMaleOmeprazolePostoperative ComplicationsProctitisPyoderma GangrenosumTomography, X-Ray Computed