Multistate Outbreak of Respiratory Infections Among Unaccompanied Children, June 2014-July 2014.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Tomczyk Sara, Arriola Carmen S, Beall Bernard, Benitez Alvaro, Benoit Stephen R, Berman LaShondra, Bresee Joseph, da Gloria Carvalho Maria, Cohn Amanda, Cross Kristen, Diaz Maureen H, Francois Watkins Louise K, Gierke Ryan, Hagan Jose E, Harris Aaron M, Jain Seema, Kim Lindsay, Kobayashi Miwako, Lindstrom Stephen, McGee Lesley, McMorrow Meredith, Metcalf Benjamin L, Moore Matthew R, Moura Iaci, Nix W Allan, Nyangoma Edith, Oberste M Steven, Olsen Sonja J, Pimenta Fabiana, Socias Christina, Thurman Kathleen, Waller Jessica, Waterman Stephen H, Westercamp Matthew, Wharton Melinda, Whitney Cynthia G, Winchell Jonas M, Wolff Bernard, Kim Curi
Аннотация
METHODS: Medical charts were abstracted for hospitalized UC. Nonhospitalized UC with influenza-like illness were interviewed, and nasopharyngeal and oropharyngeal swabs were collected to detect respiratory pathogens. Nasopharyngeal swabs were used to assess pneumococcal colonization in symptomatic and asymptomatic UC. Pneumococcal blood isolates from hospitalized UC and nasopharyngeal isolates were characterized by serotyping and whole-genome sequencing.
RESULTS: Among 15 hospitalized UC, 4 (44%) of 9 tested positive for influenza viruses, and 6 (43%) of 14 with blood cultures grew pneumococcus, all serotype 5. Among 48 nonhospitalized children with influenza-like illness, 1 or more respiratory pathogens were identified in 46 (96%). Among 774 nonhospitalized UC, 185 (24%) yielded pneumococcus, and 70 (38%) were serotype 5. UC transferring through the processing center were more likely to be colonized with serotype 5 (odds ratio, 3.8; 95% confidence interval, 2.1-6.9). Analysis of core pneumococcal genomes detected 2 related, yet independent, clusters. No pneumococcus cases were reported after pneumococcal and influenza immunization campaigns.
CONCLUSIONS: This respiratory disease outbreak was due to multiple pathogens, including Streptococcus pneumoniae serotype 5 and influenza viruses. Pneumococcal and influenza vaccinations prevented further transmission. Future efforts to prevent similar outbreaks will benefit from use of both vaccines.