Akusherstvo i ginekologiia · 2012
[Treatment of cervical carcinoma IB2 stage].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Kornovski Y, Ismail E, Kaneva M
Аннотация
OBJECTIVE: To establish the overall and disease-free survival (OS and DFS) in patients IB2 stage FIGO with primary surgical treatment or operated on after preoperative RT.
MATERIAL AND METHODS: Between 2003-2011 98 patients (FIGO IB2 stage) were operated on. 83 patients were submitted to primary surgery (radical hysterectomy class III with pelvic lymph node dissection--group 1 and 11 were operated on after preoperative RT - 30 Gy - group 2. All operated patients were submitted to adjuvant RT - 52 Gy. Four patients were operated on after NCT (neoadjuvant chemotherapy). All patients were followed between 2 and 96 months--median period of 45 months.
RESULTS: The acturial OS and DFS for all patients were estimated as 73.5% and 75.6% respectively. The OS and DFS for group 1 were estimated as 73.5% and 74.7% respectively. The OS and DFS for group 2 were estimated as 72.8% and 82%, respectively.
CONCLUSION: Stage IB2 cervical cancer is related to worse prognosis in comparison to IB1 FIGO stage, because of the higher incidence of distant metastases. Preoperative RT doesn't change the oncological outcomes. There is no statistical difference between group 1 and group 2 in terms of survival. Is important to perform paraaortic lymph node dissection and concurrent radiochemotherapy in these patients.
MATERIAL AND METHODS: Between 2003-2011 98 patients (FIGO IB2 stage) were operated on. 83 patients were submitted to primary surgery (radical hysterectomy class III with pelvic lymph node dissection--group 1 and 11 were operated on after preoperative RT - 30 Gy - group 2. All operated patients were submitted to adjuvant RT - 52 Gy. Four patients were operated on after NCT (neoadjuvant chemotherapy). All patients were followed between 2 and 96 months--median period of 45 months.
RESULTS: The acturial OS and DFS for all patients were estimated as 73.5% and 75.6% respectively. The OS and DFS for group 1 were estimated as 73.5% and 74.7% respectively. The OS and DFS for group 2 were estimated as 72.8% and 82%, respectively.
CONCLUSION: Stage IB2 cervical cancer is related to worse prognosis in comparison to IB1 FIGO stage, because of the higher incidence of distant metastases. Preoperative RT doesn't change the oncological outcomes. There is no statistical difference between group 1 and group 2 in terms of survival. Is important to perform paraaortic lymph node dissection and concurrent radiochemotherapy in these patients.