International archives of allergy and immunology · 1997
A peptide from the submandibular glands modulates inflammatory responses.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Mathison R D, Davison J S, Befus A D
Аннотация
BACKGROUND: The cervical sympathetic trunk-submandibular gland (CST-SMG) axis plays an important role in inflammation. An immunoregulatory heptapeptide, submandibular gland peptide T (SGP-T), was isolated from submandibular glands, and several of its biological activities have been identified.
RESULTS: SGP-T reduced shock-induced hypotension and allergen-induced disruption of migrating myoelectric complexes and the magnitude of smooth muscle contraction. The heptapeptide inhibited the influx of neutrophils into carrageenin-soaked sponges.
CONCLUSION: SGP-T has several biological activities that collectively help explain the ability of the CST-SMG axis to regulate inflammation.
RESULTS: SGP-T reduced shock-induced hypotension and allergen-induced disruption of migrating myoelectric complexes and the magnitude of smooth muscle contraction. The heptapeptide inhibited the influx of neutrophils into carrageenin-soaked sponges.
CONCLUSION: SGP-T has several biological activities that collectively help explain the ability of the CST-SMG axis to regulate inflammation.