Dynamical Analysis of Seizure in Epileptic Brain: a Dynamic Phase-Amplitude Coupling Estimation Approach.

Cross-frequency coupling in general and phase-amplitude coupling (PAC) as a particular form of it, provides an opportunity to investigate the complex interactions between neural oscillations in the human brain and neurological disorders such as epilepsy. Using PAC detection methods on temporal sliding windows, we developed a map of dynamic PAC evolution to investigate the spatiotemporal changes occurring during ictal transitions in a patient with intractable mesial temporal lobe epilepsy. The map is built by computing the modulation index between the amplitude of high frequency oscillations and the phase of lower frequency rhythms from the intracranial stereoelectroencephalography recordings during seizure. Our preliminary results show early abnormal PAC changes occurring in the preictal state prior to the occurrence of clinical or visible electrographic seizure onset, and suggest that dynamic PAC measures may serve as a potential clinical technique for analyzing seizure dynamics.Clinical Relevance-Application of a dynamic temporal PAC map as a new tool may provide novel insights into the neurophysiology of epileptic seizure activity and its spatio-temporal dynamics.