Медицинская библиотека · Head & neck · 2023

Outcomes for oligometastatic head and neck cancer treated with stereotactic body radiotherapy: Results from an international multi-institutional consortium.

Id Said Badr, Mutsaers Adam, Chen Hanbo, Husain Zain A, Biswas Tithi, Dagan Roi, Erler Darby, Foote Matthew, Louie Alexander V, Redmond Kristin, Ricardi Umberto, Sahgal Arjun, Poon Ian

СтатьяМногоцентровое исследованиеПеревод пока не подготовлен

Аннотация

BACKGROUND

We report the results of an international multi-institutional cohort of oligometastatic (OMD) head and neck cancer (HNC) patients treated with SBRT.

METHODS

Patients with OMD HNC (≤5 metastases) treated with SBRT between 2008 and 2016 at six institutions were included. Treated metastasis control (TMC), progression-free survival (PFS), and overall survival (OS) were analyzed by multivariable analysis (MVA).

RESULTS

Forty-two patients with 84 HNC oligometastases were analyzed. The TMC rate at 1 and 2 years were 80% and 66%, with a median time to recurrence of 10.1 months. The median PFS and OS were 4.7 and 23.3 months. MVA identified a PTV point maximum (BED)10 > 100 Gy as a predictor of improved TMC (HR = 0.31, p = 0.034), and a cumulative PTV > 48 cc as having worse PFS (HR = 2.99, p < 0.001).

CONCLUSION

Favorable TMC and OS was observed in OMD HNCs treated with SBRT.

Для цитирования: Id Said Badr, Mutsaers Adam, Chen Hanbo, Husain Zain A, Biswas Tithi, Dagan Roi, Erler Darby, Foote Matthew, Louie Alexander V, Redmond Kristin, Ricardi Umberto, Sahgal Arjun, Poon Ian. Outcomes for oligometastatic head and neck cancer treated with stereotactic body radiotherapy: Results from an international multi-institutional consortium.. Head & neck. 2023. DOI: 10.1002/hed.27488.

Предметные рубрики MeSH

Humans Head and Neck Neoplasms Lung Neoplasms Progression-Free Survival Radiosurgery Retrospective Studies Treatment Outcome

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