Auris, nasus, larynx · 2019
Efficacy of chemotherapy after progression with nivolumab in squamous cell carcinoma of the head and neck.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Suzuki Shinsuke, Toyoma Satoshi, Tomizawa Hiroki, Yamada Toshiki, Iikawa Nobuko, Shiina Kazuhiro, Saito Hidekazu, Koizumi Koh, Kawasaki Yohei, Yamada Takechiyo
Аннотация
Nivolumab, a programmed death-1 (PD-1) inhibitor, has shown promising results against squamous cell carcinoma of the head and neck (SCCHN) in cases of recurrence or in a metastatic setting after platinum-based therapy. However, treatment alternatives for patients with nivolumab-refractory are limited, and a constant opinion is not provided. Recently, accumulating studies have demonstrated that chemotherapy after immune checkpoint inhibitor treatment may induce better objective responses in patients with advanced non-small cell lung cancer. However, there are few reports on the increased effect of chemotherapy after nivolumab treatment in SCCHN. Therefore, cases must be accumulated to identify patients with nivolumab-refractory SCCHN who may benefit from chemotherapy. Here, we present patients with SCCHN who exhibited a significant response to chemotherapy after nivolumab treatment.