Metastatic solid tumors to the testis: a clinicopathologic evaluation of 157 cases from an international collaboration.
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Nova-Camacho Luiz M, Acosta Andres M, Trpkov Kiril, Sangoi Ankur R, Pierre Allaume, Chou Angela, Yilmaz Asli, Morini Aurélien, Rodrigues Ângelo, Fletcher Christopher D M, Perez-Montiel Delia, Maclean Fiona, Contreras Félix, Queipo Francisco Javier, Muñiz Unamunzaga Gorka, Mesa Hector, de Torres Inés, Ruiz Irune, Alvarado-Cabrero Isabel, Lobo João, Schwartz Lauren, Cheng Liang, Akgul Mahmut, García-Martos María, Palmer Matthew B, Aron Manju, Raspollini Maria Rosaria, Manrique Celada Manuel, Hwang Michael, Idrees Muhammad T, Rioux-Leclercq Nathalie, Zalles Nicole, Vergara Norge, Lal Priti, Wobker Sara, Kammerer-Jacquet Solène-Florence, Prendeville Susan, Tilmant Théau, Ulbright Thomas M, Verkarre Virginie, Collins Katrina, Williamson Sean R, Panizo Angel
Аннотация
To elucidate the spectrum of metastatic solid tumors to the testis and their clinicopathologic features. The databases and files of 26 pathology departments from 9 countries on 3 continents were surveyed to identify metastatic solid tumors to the testis and to characterize their clinicopathologic features in detail. We compiled a series of 157 cases of metastatic solid tumors that secondarily involved the testis. The mean patient age at diagnosis was 64 years (range, 12-93 years). Most patients (127/144; 88%) had clinical manifestation of the disease, with testicular mass/nodule (89/127; 70%) being the most common finding. The main mechanism of testicular involvement was metastasis in 154/157 (98%) cases. Bilateral testicular involvement was present in 12/157 (8%) patients. Concurrent or prior extratesticular metastases were present in 78/101 (77%) patients. The diagnosis was made mainly in orchiectomy specimens (150/157; 95%). Different types of carcinomas (138/157; 87%), most commonly adenocarcinoma (72/157; 46%), were the most common malignancies. The most common primary carcinomas included prostatic (51/149; 34%), renal (29/149; 20%), and colorectal (13/149; 9%). Intratubular growth was identified in 13/124 (11%) cases and paratesticular involvement was found in 73/152 (48%) cases. In patients with available follow-up (110/157; 70%), more than half (58/110; 53%) died of disease. In this largest series compiled to date, we found that most secondary tumors of the testis represent metastases from the genitourinary and gastrointestinal tract carcinomas and typically occur in the setting of disseminated disease.