Analytical and quantitative cytology and histology · 2008
Expression pattern of type IV collagen in sporadic dysplastic melanocytic nevi.
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Lebe Banu, Pabuççuoglu Ugur, Ozer Erdener
Аннотация
OBJECTIVE: To investigate the expression and distribution pattern of type IV collagen in dysplastic nevi (DN) and to determine whether DN exhibits a morphologic difference from common melanocytic nevi (CMN) and cutaneous malignant melanomas (MM) and therefore can be classified as a separate entity.
STUDY DESIGN: We examined 33 DN specimens, 18 CMN specimens, and 10 MM specimens. The streptavidinbiotin immunoperoxidase method was used for immunostaining.
RESULTS: No staining was observed in most of the CMN. Twenty-one of 33 DN showed a continuous pattern of type IV collagen surrounding junctional nests in a concentric fashion while a discontinuous immunostaining pattern was observed in remaining cases. Six of 10 MM showed a continuous staining pattern; 2 exhibited discontinuous staining; and in 2 cases, no immunostaining was observed. The expression pattern of type IV collagen in DN was statistically different from CMN and MM.
CONCLUSION: Our results suggest sporadic DN is biologically different from CMN in terms of the capacity to synthesize type IV collagen, demonstrating that DN is not only morphologically but also biologically a different entity from CMN.
STUDY DESIGN: We examined 33 DN specimens, 18 CMN specimens, and 10 MM specimens. The streptavidinbiotin immunoperoxidase method was used for immunostaining.
RESULTS: No staining was observed in most of the CMN. Twenty-one of 33 DN showed a continuous pattern of type IV collagen surrounding junctional nests in a concentric fashion while a discontinuous immunostaining pattern was observed in remaining cases. Six of 10 MM showed a continuous staining pattern; 2 exhibited discontinuous staining; and in 2 cases, no immunostaining was observed. The expression pattern of type IV collagen in DN was statistically different from CMN and MM.
CONCLUSION: Our results suggest sporadic DN is biologically different from CMN in terms of the capacity to synthesize type IV collagen, demonstrating that DN is not only morphologically but also biologically a different entity from CMN.