Alteration of regional heterogeneity and functional connectivity for obese undergraduates: evidence from resting-state fMRI.

Obesity was found to be related with the changes of brain functions in human beings. There were several brain areas that were verified to be correlated with the obesity, including the parietal cortex, frontal cortex and so on. However, the cortical regions found from different studies were discrepant due to the different ages, gender distribution and satiation degree of participants. We found that the regional homogeneity of right angular gyrus were smaller in obese undergraduates than that in normal-weight undergraduates. Moreover, functional connectivity of the left middle temporal cortex and the right angular gyrus were found to be smaller in obese group than that in normal-weight group by setting the right angular gyrus as seed region. In addition, multiple regression analysis suggested that the right superior frontal gyrus and left middle temporal gyrus were significantly correlated with their body mass index for normal-weight undergraduates, but no significant correlation was found for obese group. In summary, these findings indicated the functional changes of the cortex in obese undergraduates, which might be significant for providing imaging-based biomarkers for intervention and therapy of obesity.