Annals of laboratory medicine · 2025
Chromosomal Rearrangements in 1,787 Cases of Acute Leukemia in Korea over 15 Years.
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Son DongGeun, Jang Ho Cheol, Lee Young Eun, Choi Yong Jun, Park Joo Heon, Lim Ha Jin, Choi Hyun-Jung, Baek Hee Jo, Kook Hoon, Kim Mihee, Song Ga-Young, Ahn Seo-Yeon, Jung Sung-Hoon, Yang Deok-Hwan, Lee Je-Jung, Kim Hyeonug-Joon, Ahn Jae-Sook, Shin Myung-Geun
Аннотация
BACKGROUND: Chromosomal alterations serve as diagnostic and prognostic markers in acute leukemia. Given the evolving landscape of chromosomal abnormalities in acute leukemia, we previously studied these over two periods. In this study, we investigated the frequency of these abnormalities and clinical trends in acute leukemia in Korea across three time periods.
METHODS: We retrospectively analyzed data from 1,787 patients with acute leukemia (319 children and 1,468 adults) diagnosed between 2006 and 2020. Conventional cytogenetics, FISH, and multiplex quantitative PCR were used for analysis. The patient groups were divided according to the following three study periods: 2006-2009 (I), 2010-2015 (II), and 2016-2020 (III).
RESULTS: Chromosomal aberrations were detected in 92% of patients. The PML::RARA translocation was the most frequent. Over the 15-yr period, chromosomal aberrations showed minimal changes, with specific fusion transcripts being common among patients. ALL was more prevalent in children than in adults and correlated significantly with the ETV6::RUNX1 and RUNX1::RUNX1T1 aberrations. The incidence of ALL increased during the three periods, with PML::RARA remaining common.
CONCLUSIONS: The frequency of chromosomal abnormalities in acute leukemia has changed subtly over time. Notably, the age of onset of adult AML has continuously increased. Our results may help in establishing diagnoses and clinical treatment strategies and developing various molecular diagnostic platforms.
METHODS: We retrospectively analyzed data from 1,787 patients with acute leukemia (319 children and 1,468 adults) diagnosed between 2006 and 2020. Conventional cytogenetics, FISH, and multiplex quantitative PCR were used for analysis. The patient groups were divided according to the following three study periods: 2006-2009 (I), 2010-2015 (II), and 2016-2020 (III).
RESULTS: Chromosomal aberrations were detected in 92% of patients. The PML::RARA translocation was the most frequent. Over the 15-yr period, chromosomal aberrations showed minimal changes, with specific fusion transcripts being common among patients. ALL was more prevalent in children than in adults and correlated significantly with the ETV6::RUNX1 and RUNX1::RUNX1T1 aberrations. The incidence of ALL increased during the three periods, with PML::RARA remaining common.
CONCLUSIONS: The frequency of chromosomal abnormalities in acute leukemia has changed subtly over time. Notably, the age of onset of adult AML has continuously increased. Our results may help in establishing diagnoses and clinical treatment strategies and developing various molecular diagnostic platforms.
Предметные рубрики MeSH
HumansRepublic of KoreaAdultChildMaleFemaleRetrospective StudiesAdolescentChromosome AberrationsChild, PreschoolMiddle AgedIn Situ Hybridization, FluorescenceYoung AdultOncogene Proteins, FusionInfantAgedTranslocation, GeneticLeukemia, Myeloid, AcuteCore Binding Factor Alpha 2 SubunitPrecursor Cell Lymphoblastic Leukemia-LymphomaAged, 80 and over