Correlation between somatosensory function and cortical activation induced by touch stimulation in patients with intracerebral hemorrhage.

OBJECTIVES

The correlation between somatosensory function and cortical activation induced by touch stimulation in patients with intracerebral hemorrhage (ICH) was investigated by functional magnetic resonance imaging (fMRI).

METHODS

Thirty-two chronic ICH patients with somatosensory deficits in tactile sensation were enrolled. For fMRI, touch stimulation was applied on the dorsum of the affected hand (contralateral to the ICH), using a rubber brush at a frequency of 1 Hz. Regions of interests (ROIs) were set at the primary sensory-motor cortex [SM1: Brodmann's area (BA) 1, 2, 3, 4], the posterior parietal cortex (PPC: BA 5, 7) and the secondary somatosensory cortex (S2: BA 43) in both hemispheres. The tactile sensation subscale of the Nottingham Sensory Assessment (NSA) was used to determine somatosensory function.

RESULTS

Significant correlations were found between NSA scores and voxel counts in the contralateral (ipsilesional) SM1 (r = 0.642; p < 0.05), the contralateral PPC (r = 0.507; p < 0.05) and the ipsilateral (contralesional) SM1 (r = 0.466; p < 0.05). However, no correlation was found between NSA scores and the contralateral S2 (r = 0.323; p > 0.05), the ipsilateral PPC (r = 0.252; p > 0.05) or the ipsilateral S2 (r = 0.280; p > 0.05).

CONCLUSIONS

It was found that somatosensory functions were positively correlated with degrees of blood oxygenation level dependent signal change of the following ROIs: the contralateral SM1, the contralateral PPC and the ipsilateral SM1. Opposingly, the S2 showed no correlation on either side of the brain.