The Pediatric infectious disease journal · 2014
Middle East respiratory syndrome coronavirus disease in children.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Memish Ziad A, Al-Tawfiq Jaffar A, Assiri Abdullah, AlRabiah Fahad A, Al Hajjar Sami, Albarrak Ali, Flemban Hesham, Alhakeem Rafat F, Makhdoom Hatem Q, Alsubaie Sarah, Al-Rabeeah Abdullah A
Аннотация
BACKGROUND: In the initial description of Middle East respiratory syndrome coronavirus (MERS-CoV) infection, many affected patients were adults with underlying medical comorbidities. Data on the clinical presentation and outcome of pediatric cases are lacking. We report the clinical presentation and outcome of MERS-CoV infection in 11 pediatric patients.
METHODS: The clinical presentation, demographic and laboratory data of pediatric patients with MERS-CoV were analyzed.
RESULTS: A total of 11 pediatric cases that tested positive by screening and confirmatory polymerase chain reaction for MERS-CoV were reported from Saudi Arabia. Two patients were symptomatic and the other 9 cases were asymptomatic. The median age of patients was 13 (range 2-16) years. There were 8 females and 3 males (2.7:1 ratio). One symptomatic patient died and the other symptomatic patient recovered. The diagnosis of patients was based on positive nasopharyngeal swabs on 10 patients.
CONCLUSIONS: MERS-CoV disease is not limited to adults. Most cases of childhood MERS-CoV infection were asymptomatic and tested positive during contact investigation of older patients. Severe disease can occur in children with underlying conditions.
METHODS: The clinical presentation, demographic and laboratory data of pediatric patients with MERS-CoV were analyzed.
RESULTS: A total of 11 pediatric cases that tested positive by screening and confirmatory polymerase chain reaction for MERS-CoV were reported from Saudi Arabia. Two patients were symptomatic and the other 9 cases were asymptomatic. The median age of patients was 13 (range 2-16) years. There were 8 females and 3 males (2.7:1 ratio). One symptomatic patient died and the other symptomatic patient recovered. The diagnosis of patients was based on positive nasopharyngeal swabs on 10 patients.
CONCLUSIONS: MERS-CoV disease is not limited to adults. Most cases of childhood MERS-CoV infection were asymptomatic and tested positive during contact investigation of older patients. Severe disease can occur in children with underlying conditions.