Proceedings of the National Academy of Sciences of the United States of America · 2002
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод пока не подготовлен
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Calin George Adrian, Dumitru Calin Dan, Shimizu Masayoshi, Bichi Roberta, Zupo Simona, Noch Evan, Aldler Hansjuerg, Rattan Sashi, Keating Michael, Rai Kanti, Rassenti Laura, Kipps Thomas, Negrini Massimo, Bullrich Florencia, Croce Carlo M
Аннотация
Micro-RNAs (miR genes) are a large family of highly conserved noncoding genes thought to be involved in temporal and tissue-specific gene regulation. MiRs are transcribed as short hairpin precursors ( approximately 70 nt) and are processed into active 21- to 22-nt RNAs by Dicer, a ribonuclease that recognizes target mRNAs via base-pairing interactions. Here we show that miR15 and miR16 are located at chromosome 13q14, a region deleted in more than half of B cell chronic lymphocytic leukemias (B-CLL). Detailed deletion and expression analysis shows that miR15 and miR16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority ( approximately 68%) of CLL cases.
Предметные рубрики MeSH
AdultB-LymphocytesBlotting, NorthernBlotting, WesternCD5 AntigensChildChild, PreschoolChromosomes, Human, Pair 13Gene DeletionGene Expression Regulation, LeukemicHumansHybrid CellsLeukemia, Lymphocytic, Chronic, B-CellMicroRNAsMiddle AgedNeoplasmsNeoplastic Stem CellsPalatine TonsilRNA, NeoplasmReverse Transcriptase Polymerase Chain ReactionTranscription, GeneticTumor Cells, Cultured