Effects of CL-1700 and its constituents on acute or chronic gastric lesions and gastric secretion in rats.

Effects of CL-1700 (N-acetyl-L-carnosine aluminum) and its constituents, L-carnosine, N-acetyl-L-carnosine and Al(OH)3 on acute or chronic gastric lesions in intact rats and on gastric secretion in pylorus-ligated rats were studied. CL-1700 at 600 or 1,000 mg/kg p.o markedly inhibited Shay ulcers or indomethacin-induced erosions, but its constituents at the doses contained in CL-1700 did not. Also, CL-1700 at 300 mg/kg i.p. significantly inhibited water-immersion stress-induced erosions, but its constituents did not. CL-1700 at 600 mg/kg i.p. and Al(OH)3 at 143 mg/kg i.p. significantly inhibited Shay ulcers. CL-1700 at 1,000 mg/kg p.o. almost completely inhibited aspirin- or histamine-induced erosions, but both L-carnosine at 639 mg/kg p.o. and N-acetyl-L-carnosine at 817 mg/kg p.o. also markedly inhibited the formation of erosions. CL-1700 at 1,000 mg/kg p.o. increased the volume and raised the pH value, and the agent at 600 mg/kg i.p. reduced the acid output. CL-1700 at 1,000 mg/kg/day p.o. given twice daily for 3 weeks diminished the size of acetic acid ulcers and significantly increased the number of rats with healed ulcers.