Cancer genetics and cytogenetics · 2005
TEL-AML1 frequency in multi-ethnic Malaysian pediatric acute lymphoblastic leukemia.
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Gill Harvindar Kaur, Keoh Ten Sew, Dhaliwal Jasbir Singh, Moore Sarah, Kim Tan Sew, Hassan Roshida, Karim Faraiza Abdul, Zakaria Zubaidah, Murad Shahnaz, Mohamed Mahfuzah, Li Ho Caroline Mei, Ibrahim Hishamshah, Rahman Eni Juraida Abdul
Аннотация
Eighty-eight multi-ethnic Malaysian pediatric acute lymphoblastic leukemia (ALL) patients were screened for the TEL-AML1 rearrangement by reverse transcription-polymerase chain reaction (RT-PCR). Fluorescence in situ hybridization (FISH) was used as an independent screen for 30 cases and to confirm RT-PCR positive cases. Seventeen patients, or 19%, were found to be t(12;21) positive. Ethnically the group comprised 12 Malays, 4 Chinese, and 1 Indian. All patients, including 1 with an unusual blast cell morphology who suffered an early relapse and death, were characteristic TEL-AML1 cases in cell count, age, ALL subset classification, and fusion transcript expressed. This study shows that in Malaysia, TEL-AML1 is found in the same distinct ALL subset and at a similar frequency as in other diverse childhood ALL cohorts.