Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025

Alpha rhythm and Alzheimer's disease: Has Hans Berger's dream come true?

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Babiloni Claudio, Arakaki Xianghong, Baez Sandra, Barry Robert J, Benussi Alberto, Blinowska Katarzyna, Bonanni Laura, Borroni Barbara, Bayard Jorge Bosch, Bruno Giuseppe, Cacciotti Alessia, Carducci Filippo, Carino John, Carpi Matteo, Conte Antonella, Cruzat Josephine, D'Antonio Fabrizia, Della Penna Stefania, Del Percio Claudio, De Sanctis Pierfilippo, Escudero Javier, Fabbrini Giovanni, Farina Francesca R, Fraga Francisco J, Fuhr Peter, Gschwandtner Ute, Güntekin Bahar, Guo Yi, Hajos Mihaly, Hallett Mark, Hampel Harald, Hanoğlu Lutfu, Haraldsen Ira, Hassan Mahmoud, Hatlestad-Hall Christoffer, Horváth András Attila, Ibanez Agustin, Infarinato Francesco, Jaramillo-Jimenez Alberto, Jeong Jaeseung, Jiang Yang, Kamiński Maciej, Koch Giacomo, Kumar Sanjeev, Leodori Giorgio, Li Gang, Lizio Roberta, Lopez Susanna, Ferri Raffaele, Maestú Fernando, Marra Camillo, Marzetti Laura, McGeown William, Miraglia Francesca, Moguilner Sebastian, Moretti Davide V, Mushtaq Faisal, Noce Giuseppe, Nucci Lorenzo, Ochoa John, Onorati Paolo, Padovani Alessandro, Pappalettera Chiara, Parra Mario Alfredo, Pardini Matteo, Pascual-Marqui Roberto, Paulus Walter, Pizzella Vittorio, Prado Pavel, Rauchs Géraldine, Ritter Petra, Salvatore Marco, Santamaria-García Hernando, Schirner Michael, Soricelli Andrea, Taylor John-Paul, Tankisi Hatice, Tecchio Franca, Teipel Stefan, Kodamullil Alpha Tom, Triggiani Antonio Ivano, Valdes-Sosa Mitchell, Valdes-Sosa Pedro, Vecchio Fabrizio, Vossel Keith, Yao Dezhong, Yener Görsev, Ziemann Ulf, Kamondi Anita

Аннотация

In this "centenary" paper, an expert panel revisited Hans Berger's groundbreaking discovery of human restingstate electroencephalographic (rsEEG) alpha rhythms (8-12 Hz) in 1924, his foresight of substantial clinical applications in patients with "senile dementia," and new developments in the field, focusing on Alzheimer's disease (AD), the most prevalent cause of dementia in pathological aging. Clinical guidelines issued in 2024 by the US National Institute on Aging-Alzheimer's Association (NIA-AA) and the European Neuroscience Societies did not endorse routine use of rsEEG biomarkers in the clinical workup of older adults with cognitive impairment. Nevertheless, the expert panel highlighted decades of research from independent workgroups and different techniques showing consistent evidence that abnormalities in rsEEG delta, theta, and alpha rhythms (< 30 Hz) observed in AD patients correlate with wellestablished AD biomarkers of neuropathology, neurodegeneration, and cognitive decline. We posit that these abnormalities may reflect alterations in oscillatory synchronization within subcortical and cortical circuits, inducing cortical inhibitory-excitatory imbalance (in some cases leading to epileptiform activity) and vigilance dysfunctions (e.g., mental fatigue and drowsiness), which may impact AD patients' quality of life. Berger's vision of using EEG to understand and manage dementia in pathological aging is still actual.

Предметные рубрики MeSH

Humans Alpha Rhythm Alzheimer Disease Brain Electroencephalography History, 20th Century

Alpha rhythm and Alzheimer's disease: Has Hans Berger's dream come true?

Ошибки и ограничения

Аннотация

Предметные рубрики MeSH