Medical and pediatric oncology · 2001
Analysis of handwriting of children during treatment for acute lymphoblastic leukemia.
Клиническое исследованиеСравнительное исследованиеКонтролируемое клиническое исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Reinders-Messelink H A, Schoemaker M M, Snijders T A, Göeken L N, Bökkerink J P, Kamps W A
Аннотация
BACKGROUND: Children treated for acute lymphoblastic leukemia (ALL) often complain about handwriting problems.
PROCEDURE: Using a computerized writing task, we have prospectively studied the processes necessary for the production of handwriting movements in 11 children (5-12 years old) during treatment for ALL. Children were tested at time points closely related to the vincristine administration.
RESULTS AND CONCLUSIONS: Children treated for ALL drew slower, with longer pause durations and increased drawing pressure. Children were able to overcome the problems, except for a consistently increased drawing pressure. This increased drawing pressure may be an attempt of the children to obtain sufficient kinesthetic information and thus can be seen as an adequate adaptation mechanism in case of peripheral neuropathy due to the neurotoxic effects of vincristine. However, neurotoxic effects of other cytostatic drugs cannot be excluded.
PROCEDURE: Using a computerized writing task, we have prospectively studied the processes necessary for the production of handwriting movements in 11 children (5-12 years old) during treatment for ALL. Children were tested at time points closely related to the vincristine administration.
RESULTS AND CONCLUSIONS: Children treated for ALL drew slower, with longer pause durations and increased drawing pressure. Children were able to overcome the problems, except for a consistently increased drawing pressure. This increased drawing pressure may be an attempt of the children to obtain sufficient kinesthetic information and thus can be seen as an adequate adaptation mechanism in case of peripheral neuropathy due to the neurotoxic effects of vincristine. However, neurotoxic effects of other cytostatic drugs cannot be excluded.
Предметные рубрики MeSH
Analysis of VarianceAntineoplastic Combined Chemotherapy ProtocolsChildChild, PreschoolDose-Response Relationship, DrugFemaleFollow-Up StudiesHumansMaleMotor SkillsPeripheral Nervous System DiseasesPrecursor Cell Lymphoblastic Leukemia-LymphomaProbabilityProspective StudiesRisk AssessmentSensitivity and SpecificityStatistics, NonparametricVincristineWriting