Science (New York, N.Y.) · 2026
Psilocybin prevents chemotherapy-induced peripheral neuropathy through mitochondrial trafficking preservation.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Heles Mario, Pasvolsky Lilach, Sathishkumar Hinduja, Naara Shorook, Vu Yen, Stewart Caitlyn L, Xie Tongxin, Gleber-Netto Frederico O, McCarthy William, Yaniv Dan, Kamal Shashank S, Elahi Hajira, Zhu Pengyu, Uhelski Megan L, Chatwin Jordan, Lara Andrew, Stolley Danielle L, Migden Michael R, Lee Z-Hye, Thevasagayampillai Shiyanth, Gunaratne Preethi H, Ait-Ahmad Kaoutar, Kuykendall M J, Eksi Sebnem Ece, Cohen Lorenzo, Borniger Jeremy C, Gottlieb Eyal, Jones Gregory H, Dougherty Patrick M, Amit Moran
Аннотация
Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling, often irreversible toxicity that affects millions of patients, limits life-saving cancer therapy, and lacks proven treatment. In this work, we show that as little as two doses of psilocybin before chemotherapy durably prevented the onset of CIPN across platinum- and taxane-based models, including repeated chemotherapy cycles, without impairing antitumor efficacy. Peripherally, psilocybin maintained tactile sensitivity and intraepidermal nerve fiber endings through axonal mitochondrial trafficking and distribution preservation, through the TrkB-Akt-PAK5-MAP2-KIF5B pathway and remobilization of syntaphilin-anchored mitochondria. Centrally, it normalized medial prefrontal cortical synaptic activity and cortical alpha and beta electroencephalography power. This stabilization of peripheral axonal energy balance establishes psilocybin as a first-in-class prophylactic agent for CIPN while also preserving central neural function. Given psilocybin's established safety, these discoveries support clinical evaluation as a strategy to prevent CIPN.