Clinical lymphoma, myeloma & leukemia · 2018
Extralymphatic Disease Is an Independent Prognostic Factor in Hodgkin Lymphoma.
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Gaudio Francesco, Pedote Pasquale, Asabella Artor Niccoli, Perrone Tommasina, Laddaga Filomena Emanuela, Sindaco Paola, Cimmino Antonia, D'Abbicco Dario, Pezzolla Angela, Rubini Giuseppe, Specchia Giorgina
Аннотация
PURPOSE: To identify the characteristics and outcomes of patients with extralymphatic Hodgkin lymphoma.
PATIENTS AND METHODS: We performed a retrospective single-institution study of 341 cases comprising 207 male (61%) and 134 female (39%) subjects with a median follow-up of 44 months.
RESULTS: Fifty-five patients (16%) had extralymphatic disease. The sites were lung in 29 patients (44%), bone in 22 (33%), liver in 12 (18%), and kidney in 3 (5%). In 46 patients (86%) only one organ was involved, while in 7 patients (13%) extralymphatic disease was present in 2 sites and in 2 patients (3%) in 3 sites. The extralymphatic disease group had a poorer prognosis than the lymphatic disease group. Complete remission rates in the extralymphatic and lymphatic patient subsets were 65% and 82% (P = .043), respectively.
CONCLUSION: Extralymphatic disease in patients with Hodgkin lymphoma is a rare occurrence (16%) associated with poor clinical outcome.
PATIENTS AND METHODS: We performed a retrospective single-institution study of 341 cases comprising 207 male (61%) and 134 female (39%) subjects with a median follow-up of 44 months.
RESULTS: Fifty-five patients (16%) had extralymphatic disease. The sites were lung in 29 patients (44%), bone in 22 (33%), liver in 12 (18%), and kidney in 3 (5%). In 46 patients (86%) only one organ was involved, while in 7 patients (13%) extralymphatic disease was present in 2 sites and in 2 patients (3%) in 3 sites. The extralymphatic disease group had a poorer prognosis than the lymphatic disease group. Complete remission rates in the extralymphatic and lymphatic patient subsets were 65% and 82% (P = .043), respectively.
CONCLUSION: Extralymphatic disease in patients with Hodgkin lymphoma is a rare occurrence (16%) associated with poor clinical outcome.
Предметные рубрики MeSH
AdolescentAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBone NeoplasmsChemoradiotherapyFemaleFollow-Up StudiesHodgkin DiseaseHumansKidney NeoplasmsLiver NeoplasmsLung NeoplasmsMaleMiddle AgedPrognosisProgression-Free SurvivalRetrospective StudiesSurvival AnalysisYoung Adult