Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2017
Age of diagnosis, incidence and prevalence of recurrent respiratory papillomatosis-A South African perspective.
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Seedat R Y, Schall R
Аннотация
OBJECTIVES: To determine the distribution of the age of diagnosis of recurrent respiratory papillomatosis (RRP) and to determine the incidence and prevalence of RRP in both adults and children in the Free State province of South Africa in order to provide data from a population in sub-Saharan African.
DESIGN: Retrospective record review.
PARTICIPANTS: All patients with RRP in the Free State province of South Africa between 2011 and 2015.
MAIN OUTCOME MEASURES: Distribution of the age of diagnosis of RRP and incidence and prevalence of RRP.
RESULTS: The best fitting mixture distribution for the age of diagnosis of RRP was a two-component mixture of log-normal distributions. Within the first component (JoRRP), the age of diagnosis was significantly lower in patients with human papillomavirus (HPV)11 disease (median 3.2 year) than those with HPV6 disease (median 5.6 years) (P = .021), while in the second component (AoRRP), there was no significant difference in the age of diagnosis between HPV11 disease (30.7 year) and HPV6 disease (median 44.0 years) (P = .0696). The incidence and prevalence of JoRRP were 1.34/100000 population/year and 3.88/100000 population, respectively, while the incidence and prevalence of AoRRP were 0.18/100000 population/year and 0.38/100000 population, respectively.
CONCLUSION: Recurrent respiratory papillomatosis in the Free State province of South Africa is a disease with a predominantly juvenile onset, with AoRRP having a lower prevalence than in Europe. This is probably reflective of the situation in sub-Saharan Africa.
DESIGN: Retrospective record review.
PARTICIPANTS: All patients with RRP in the Free State province of South Africa between 2011 and 2015.
MAIN OUTCOME MEASURES: Distribution of the age of diagnosis of RRP and incidence and prevalence of RRP.
RESULTS: The best fitting mixture distribution for the age of diagnosis of RRP was a two-component mixture of log-normal distributions. Within the first component (JoRRP), the age of diagnosis was significantly lower in patients with human papillomavirus (HPV)11 disease (median 3.2 year) than those with HPV6 disease (median 5.6 years) (P = .021), while in the second component (AoRRP), there was no significant difference in the age of diagnosis between HPV11 disease (30.7 year) and HPV6 disease (median 44.0 years) (P = .0696). The incidence and prevalence of JoRRP were 1.34/100000 population/year and 3.88/100000 population, respectively, while the incidence and prevalence of AoRRP were 0.18/100000 population/year and 0.38/100000 population, respectively.
CONCLUSION: Recurrent respiratory papillomatosis in the Free State province of South Africa is a disease with a predominantly juvenile onset, with AoRRP having a lower prevalence than in Europe. This is probably reflective of the situation in sub-Saharan Africa.