Dermatology (Basel, Switzerland) · 1997
Expression of NM23 protein in acquired melanocytic nevi, malignant melanoma and metastases of malignant melanoma: an immunohistological assessment in human skin.
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Reichrath J, Seyfried P, Braun R, Müller S M, Baum H P, Bahmer F A
Аннотация
BACKGROUND: It has been suggested that nm23 may exert metastasis suppressor function in human tumors.
OBJECTIVE: We have analyzed expression of nm23 polypeptide in acquired melanocytic nevi (n = 19), dysplastic nevi (n = 19), malignant melanomas (n = 22) and metastases of malignant melanomas (n = 47) in situ.
METHODS: Nm23 protein was detected immunohistochemically on paraffin sections using the highly sensitive labeled avidin-biotin technique.
RESULTS: We found that (1) nm23 polypeptide is predominantly expressed in the cytoplasmic but also in nuclear and membrane compartments of melanocytic human cells, (2) expression of nm23 protein does not correlate with benign or malignant phenotype in melanocytic tumors of human skin.
CONCLUSION: Our study challenges the hypothesis that nm23 may function in malignant melanomas as a tumor suppressor gene.
OBJECTIVE: We have analyzed expression of nm23 polypeptide in acquired melanocytic nevi (n = 19), dysplastic nevi (n = 19), malignant melanomas (n = 22) and metastases of malignant melanomas (n = 47) in situ.
METHODS: Nm23 protein was detected immunohistochemically on paraffin sections using the highly sensitive labeled avidin-biotin technique.
RESULTS: We found that (1) nm23 polypeptide is predominantly expressed in the cytoplasmic but also in nuclear and membrane compartments of melanocytic human cells, (2) expression of nm23 protein does not correlate with benign or malignant phenotype in melanocytic tumors of human skin.
CONCLUSION: Our study challenges the hypothesis that nm23 may function in malignant melanomas as a tumor suppressor gene.
Предметные рубрики MeSH
Antigens, NeoplasmBiomarkers, TumorCell NucleusCytoplasmDysplastic Nevus SyndromeGene Expression Regulation, NeoplasticGenes, Tumor SuppressorHumansImmunoenzyme TechniquesImmunohistochemistryIntracellular MembranesMelanocytesMelanomaMonomeric GTP-Binding ProteinsNM23 Nucleoside Diphosphate KinasesNevus, PigmentedNucleoside-Diphosphate KinaseParaffin EmbeddingPhenotypeSkin NeoplasmsTranscription Factors