International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2009
Prevalence of HPV infection by cervical cytologic status in Brazil.
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Fernandes José Veríssimo, Meissner Rosely de Vasconcellos, de Carvalho Maria Goretti Freire, Fernandes Thales Allyrio Araújo de Medeiros, de Azevedo Paulo Roberto Medeiros, Villa Luisa Lina
Аннотация
OBJECTIVES: To assess the prevalence of human papillomavirus (HPV) infection according to cervical cytologic status in northeastern Brazil; identify other risk factors for low- and high-grade squamous intraepithelial lesions (LSILs and HSILs); and identify the most prevalent HPV genotypes associated with the lesions.
METHOD: Two cervical smears were collected from 250 women referred for cancer screening, one for cytologic examination and the other to test for the presence of HPV by PCR with genotyping by dot blot hybridization.
RESULT: There were 110 healthy cervices, 82 LSILs, and 58 HSILs. The overall HPV prevalence was 48%, with higher rates for HSILs, and HPV-16 was the most prevalent type. Age, multiple sexual partners, type of HPV present, smoking, and early onset of sexual activity were risk factors for cervical lesions.
CONCLUSION: Age, multiple sexual partners, and infection with HPV-16 increased the risk of having LSILs or HSILs. Early onset of sexual activity and smoking only increased the risk of having HSILs.
METHOD: Two cervical smears were collected from 250 women referred for cancer screening, one for cytologic examination and the other to test for the presence of HPV by PCR with genotyping by dot blot hybridization.
RESULT: There were 110 healthy cervices, 82 LSILs, and 58 HSILs. The overall HPV prevalence was 48%, with higher rates for HSILs, and HPV-16 was the most prevalent type. Age, multiple sexual partners, type of HPV present, smoking, and early onset of sexual activity were risk factors for cervical lesions.
CONCLUSION: Age, multiple sexual partners, and infection with HPV-16 increased the risk of having LSILs or HSILs. Early onset of sexual activity and smoking only increased the risk of having HSILs.
Предметные рубрики MeSH
AdolescentAdultAge FactorsAgedBrazilCervix UteriFemaleGenotypeHuman papillomavirus 16HumansImmunoblottingMiddle AgedPapillomaviridaePapillomavirus InfectionsPolymerase Chain ReactionPrevalenceRisk FactorsSexual PartnersSmokingUterine Cervical NeoplasmsVaginal SmearsYoung AdultUterine Cervical Dysplasia