European journal of gynaecological oncology · 2008
Self-sampling for human papillomavirus (HPV) testing as cervical cancer screening option. Experience from the LAMS study.
Сравнительное исследованиеСтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Longatto-Filho A, Roteli-Martins C, Hammes L, Etlinger D, Pereira S M Miranda, Erzen M, Branca M, Naud P, Derchain S F M, Sarian L O, Matos J, Gontijo R, Lima T, Maeda M Y S, Tatti S, Syrjänen S, Syrjänen K
Аннотация
PURPOSE: To compare Hybrid Capture II (HC2) in detecting high-risk (HR) HPV in patient-collected vaginal samples with those obtained using gynaecologist collected samples.
METHODS: Patients were submitted to Pap smears, visual inspection with acetic acid (VIA) and HC2 for hr-HPV.
RESULTS: A total of 1,081 HC2 tests for HR-HPV were performed: 770 (71.2%) samples were collected by a physician and 311 (28.8%) were self-collected by the patients. In detecting any cervical lesion, the sensitivity of HC2 collected by a physician was higher (92.86%) than that (37.5%) in the self-sampling group. Negative predictive value (NPV) was high for both, 99.69% and 93.75%, respectively. Using the CIN2 cutoff, performance of HC2 was significantly improved: 92.9% and 62.5%, respectively. HC2 specificity for any cervical lesion and for CIN2 or higher were close to 90% in both groups.
CONCLUSIONS: Self-sampled HPV testing is a powerful option to increase the detection of cervical lesions in women segregated from prevention programs.
METHODS: Patients were submitted to Pap smears, visual inspection with acetic acid (VIA) and HC2 for hr-HPV.
RESULTS: A total of 1,081 HC2 tests for HR-HPV were performed: 770 (71.2%) samples were collected by a physician and 311 (28.8%) were self-collected by the patients. In detecting any cervical lesion, the sensitivity of HC2 collected by a physician was higher (92.86%) than that (37.5%) in the self-sampling group. Negative predictive value (NPV) was high for both, 99.69% and 93.75%, respectively. Using the CIN2 cutoff, performance of HC2 was significantly improved: 92.9% and 62.5%, respectively. HC2 specificity for any cervical lesion and for CIN2 or higher were close to 90% in both groups.
CONCLUSIONS: Self-sampled HPV testing is a powerful option to increase the detection of cervical lesions in women segregated from prevention programs.
Предметные рубрики MeSH
AdultCohort StudiesFemaleHumansLatin AmericaMass ScreeningMiddle AgedPapanicolaou TestPapillomaviridaePapillomavirus InfectionsPredictive Value of TestsPrevalenceProspective StudiesReagent Kits, DiagnosticSelf-ExaminationSensitivity and SpecificitySpecimen HandlingUterine Cervical NeoplasmsVaginal SmearsUterine Cervical Dysplasia