Reproduction, fertility, and development · 2026
Systemic complement C3 reduction in infertile women with endometrial dysbiosis: preliminary observations.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yamaguchi Shinya, Sato Takumi, Matsumi Hirotaka
Аннотация
CONTEXT: Endometrial dysbiosis has been linked to infertility, but its relationship with systemic immune activity remains unclear.
AIMS: To examine whether endometrial microbiota phenotype is associated with serum complement profiles in infertile women.
METHODS: We enrolled 105 infertile women and classified endometrial microbiota by 16S rRNA gene sequencing as Lactobacillus-dominant microbiota (LDM) or non-LDM (NLDM). Complement data were available in 27 women: after excluding cases with missing C-reactive protein (CRP; n = 2) or CRP above the 95th percentile (n = 2), 23 women were analyzed for C3/C4 and 19 for CH50. Group comparisons used Welch's t-test and Fisher's exact test.
KEY RESULTS: NLDM was associated with lower serum C3 than LDM (101.5 ± 12.4 vs 121.0 ± 18.0 mg/dL; P = 0.006). C4 and CH50 did not differ significantly between groups.
CONCLUSIONS: Endometrial dysbiosis was associated with selective C3 reduction in this infertile cohort, consistent with mild complement consumption.
IMPLICATIONS: Serum C3, interpreted with microbiota profiling, may provide a practical adjunct marker of inflammation-related infertility in routine care. Larger prospective studies are needed to validate these preliminary findings.
AIMS: To examine whether endometrial microbiota phenotype is associated with serum complement profiles in infertile women.
METHODS: We enrolled 105 infertile women and classified endometrial microbiota by 16S rRNA gene sequencing as Lactobacillus-dominant microbiota (LDM) or non-LDM (NLDM). Complement data were available in 27 women: after excluding cases with missing C-reactive protein (CRP; n = 2) or CRP above the 95th percentile (n = 2), 23 women were analyzed for C3/C4 and 19 for CH50. Group comparisons used Welch's t-test and Fisher's exact test.
KEY RESULTS: NLDM was associated with lower serum C3 than LDM (101.5 ± 12.4 vs 121.0 ± 18.0 mg/dL; P = 0.006). C4 and CH50 did not differ significantly between groups.
CONCLUSIONS: Endometrial dysbiosis was associated with selective C3 reduction in this infertile cohort, consistent with mild complement consumption.
IMPLICATIONS: Serum C3, interpreted with microbiota profiling, may provide a practical adjunct marker of inflammation-related infertility in routine care. Larger prospective studies are needed to validate these preliminary findings.