BMC research notes · 2026
Comparative hemostatic efficacy of oxidized regenerated cellulose powder and fibrin glue in a rat model of induced liver parenchymal hemorrhage.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Acar Berkan, Çelik Abdulkadir, Kocamaz Arslan Hasan, Kişi Ömer, Varman Alper, Alkan Selman, Fındık Sıdıka, Kılınç İbrahim, Şentürk Mustafa, Küçükkartallar Tevfik
Аннотация
AIM: The objective of this study is to compare the hemostatic efficacy of oxidised regenerated cellulose powder (Surgicel® Powder) and fibrin glue (Tisseel®) in a rat model of liver parenchymal haemorrhage, and to evaluate their effects on tissue healing.
RESULTS: Preoperative haemoglobin and haematocrit values were comparable among the groups (p > 0.05). At 24 h, postoperative haemoglobin and haematocrit values differed significantly among the three groups (p = 0.045 and p = 0.042, respectively), with lower values in the saline-compression control group and relatively preserved values in the Surgicel® Powder and Tisseel® groups. However, no statistically significant difference was identified between the two active treatment groups. Histopathological evaluation revealed no statistically significant between-group differences in necrosis, inflammation, fibrosis, haemorrhage, or granulation tissue formation (p > 0.05).
RESULTS: Preoperative haemoglobin and haematocrit values were comparable among the groups (p > 0.05). At 24 h, postoperative haemoglobin and haematocrit values differed significantly among the three groups (p = 0.045 and p = 0.042, respectively), with lower values in the saline-compression control group and relatively preserved values in the Surgicel® Powder and Tisseel® groups. However, no statistically significant difference was identified between the two active treatment groups. Histopathological evaluation revealed no statistically significant between-group differences in necrosis, inflammation, fibrosis, haemorrhage, or granulation tissue formation (p > 0.05).