BMC veterinary research · 2026
Unique occurrence of trichilemmal carcinoma in the scrotal skin of a giant panda: a pathological analysis.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Li Chengyao, Xiong Zongliang, Ling Shanshan, Zhu Yan, Deng Linhua, Yang Mengfang, Wang Chengdong, Wang Qian, Chen Danyu, Huang Mao, Wang Kao, Li Desheng, Chen Zhengli, Li Caiwu
Аннотация
BACKGROUND: Trichilemmal carcinoma (TC) is a rare cutaneous appendage malignancy with scarce human cases and very few animal cases have been documented in the available literature, especially in giant pandas.
CASE PRESENTATION: A 23-year-old male captive giant panda had 4-week scrotal hyperplasia and ulceration, with a 4.5 cm×4 cm irregular lesion and neutrophils were elevated. Pathology revealed dermal lobular/cord-like invasive atypical clear cells, squamous nests and outer root sheath cysts. PAS staining was positive. Immunohistochemistry showed Her-2 (+), CK5/6 (++), p63 (++), Ki-67 (+), CD34 (+), and p53 (+), excluding squamous cell carcinoma and trichofolliculoma. Local resection (0.8 cm margin) was done under general anesthesia. Postoperative anti-infection led to 2-week wound healing; 3-month follow-up showed no recurrence with normal behavior.
CONCLUSIONS: This first reported giant panda TC with human-like immunophenotype provides evidence for managing rare animal cutaneous appendage tumors.
CASE PRESENTATION: A 23-year-old male captive giant panda had 4-week scrotal hyperplasia and ulceration, with a 4.5 cm×4 cm irregular lesion and neutrophils were elevated. Pathology revealed dermal lobular/cord-like invasive atypical clear cells, squamous nests and outer root sheath cysts. PAS staining was positive. Immunohistochemistry showed Her-2 (+), CK5/6 (++), p63 (++), Ki-67 (+), CD34 (+), and p53 (+), excluding squamous cell carcinoma and trichofolliculoma. Local resection (0.8 cm margin) was done under general anesthesia. Postoperative anti-infection led to 2-week wound healing; 3-month follow-up showed no recurrence with normal behavior.
CONCLUSIONS: This first reported giant panda TC with human-like immunophenotype provides evidence for managing rare animal cutaneous appendage tumors.