Tremor and other hyperkinetic movements (New York, N.Y.) · 2020
Dramatic Response to Pramipexole in Delayed-Onset Parkinsonism from Osmotic Demyelinating Syndrome.
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Han Steve C, Katus Linn, Frucht Steven
Аннотация
BACKGROUND: Delayed parkinsonism and dystonia are recognized phenomena in osmotic demyelinating syndrome (ODS). Dopamine receptor agonists and levodopa have been reported to benefit select patients.
CASE REPORT: We report a patient with ODS with severe pseudobulbar deficits, parkinsonism and dystonia, poorly responsive to levodopa, who experienced a remarkable improvement with pramipexole.
DISCUSSION: A marked response to pramipexole with lack of response to levodopa suggests a pre-synaptic source for his deficits coupled with injuries to non-nigral compensatory structures.
HIGHLIGHTS: This case highlights a dramatic response of osmotic demyelination-induced parkinsonism/dystonia to pramipexole. A lack of response to levodopa suggests deficits in the pre-synaptic nigral as well as non-nigral compensatory structures.
CASE REPORT: We report a patient with ODS with severe pseudobulbar deficits, parkinsonism and dystonia, poorly responsive to levodopa, who experienced a remarkable improvement with pramipexole.
DISCUSSION: A marked response to pramipexole with lack of response to levodopa suggests a pre-synaptic source for his deficits coupled with injuries to non-nigral compensatory structures.
HIGHLIGHTS: This case highlights a dramatic response of osmotic demyelination-induced parkinsonism/dystonia to pramipexole. A lack of response to levodopa suggests deficits in the pre-synaptic nigral as well as non-nigral compensatory structures.
Предметные рубрики MeSH
AdultAntiparkinson AgentsDeamino Arginine VasopressinDemyelinating DiseasesDystoniaEpistaxisHemostaticsHumansHyponatremiaLevodopaLocked-In SyndromeMaleMyelinolysis, Central PontineOsmotic PressureParkinsonian DisordersPostoperative HemorrhagePramipexolePseudobulbar PalsyRhinoplastyTetrahydronaphthalenesThiophenesTreatment FailureTreatment Outcomevon Willebrand Disease, Type 1