Revista de gastroenterologia de Mexico (English) · 2026
Hepatic involvement as the initial manifestation of B-cell acute lymphoblastic leukemia in adults: A case series.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Chávez-Sánchez S A, Bellido-Caparó A, García-Encinas C A, Padilla-Machaca P M
Аннотация
INTRODUCTION: Hepatic involvement as an initial presentation of acute lymphoblastic leukemia (ALL) in adults is rare and may delay the diagnosis.
MATERIAL AND METHODS: A case series of adult patients with confirmed B-cell ALL (B-ALL) and altered liver function tests at disease onset was conducted. Clinical, biochemical, imaging, and flow cytometry data were collected, ruling out infectious, autoimmune, and toxic etiologies.
RESULTS: Three men, 68, 36, and 38 years of age, presented with cholestasis and hepatosplenomegaly with no biliary tract dilation. Flow cytometry showed high percentages of B lymphoblasts. One patient died shortly after starting chemotherapy and the other two remain on active treatment.
CONCLUSION: Hepatic infiltration due to ALL should be considered in the differential diagnosis of cholestasis with a normal biliary tract in adults.
MATERIAL AND METHODS: A case series of adult patients with confirmed B-cell ALL (B-ALL) and altered liver function tests at disease onset was conducted. Clinical, biochemical, imaging, and flow cytometry data were collected, ruling out infectious, autoimmune, and toxic etiologies.
RESULTS: Three men, 68, 36, and 38 years of age, presented with cholestasis and hepatosplenomegaly with no biliary tract dilation. Flow cytometry showed high percentages of B lymphoblasts. One patient died shortly after starting chemotherapy and the other two remain on active treatment.
CONCLUSION: Hepatic infiltration due to ALL should be considered in the differential diagnosis of cholestasis with a normal biliary tract in adults.